Scholarlink

Objective <p>Platelet antibodies are associated with adverse pregnancy outcomes, such as miscarriage and fetal/neonatal alloimmune thrombocytopenia (FNAIT). However, data on their prevalence and risk factors in the&#xa0;southern Chinese population remain limited. This study aimed to investigate the prevalence of platelet antibodies and their risk factors in pregnant women from southern China, with a particular focus on their association with thyroid diseases.</p> Methods <p>Blood samples from 5,037 pregnant women&#xa0;presenting for delivery&#xa0;between June 30, 2022, and April 7, 2024, were screened for platelet antibodies via the solid-phase agglutination test. Participants were categorized as&#xa0;platelet antibody positive or negative based on the test results. Clinical data were compared between the two groups. Binary logistic regression analysis was performed to identify&#xa0;independent risk factors for platelet antibody positivity.</p> Results <p>The overall platelet antibody positivity rate was 7.68%. The positivity increased significantly with&#xa0;both a greater number of pregnancies and a history of miscarriage. Notably, thyroid diseases were strongly associated with platelet antibodies:&#xa0;women with thyroid diseases had a significantly higher positivity rate of 11.55%. Specifically, Hashimoto’s thyroiditis (HT) and thyroid nodules were identified as&#xa0;significant independent risk factors in the binary logistic regression analysis. Other significant independent risk factors included&#xa0;a history of blood transfusion, three or more pregnancies, three or more miscarriages, and thalassemia.</p> Conclusions <p>This study provides&#xa0;novel evidence&#xa0;of&#xa0;a significant association between maternal thyroid disorders (particularly HT and thyroid nodules) and a higher prevalence of platelet antibodies during pregnancy. These findings highlight the importance of considering thyroid status in antenatal care and&#xa0;suggest a potential benefit of proactive platelet antibody screening, especially in women with thyroid diseases, to help mitigate associated risks such as miscarriage and FNAIT.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Thyroid Diseases Identified as an Independent Risk Factor for Platelet Antibody Positivity in Pregnant Women: A Single-Center Study from Southern China

  • 期刊论文

  • 发表日期：

    2026年4月10日

查看全文
  • Pei-bin Lai,
  • Xiao-fang Liu,
  • Cai-han Zhao,
  • Jing-lin Shao,
  • Zhi-hua Cen,
  • Bao-ying Feng,
  • Lu-kun Guo,
  • Li-juan Xu,
  • Yang Liu,
  • Qing Yuan,
  • Ying Lu,
  • Jun-jie Bao,
  • Yong Zou

摘要

Objective

Platelet antibodies are associated with adverse pregnancy outcomes, such as miscarriage and fetal/neonatal alloimmune thrombocytopenia (FNAIT). However, data on their prevalence and risk factors in the southern Chinese population remain limited. This study aimed to investigate the prevalence of platelet antibodies and their risk factors in pregnant women from southern China, with a particular focus on their association with thyroid diseases.

Methods

Blood samples from 5,037 pregnant women presenting for delivery between June 30, 2022, and April 7, 2024, were screened for platelet antibodies via the solid-phase agglutination test. Participants were categorized as platelet antibody positive or negative based on the test results. Clinical data were compared between the two groups. Binary logistic regression analysis was performed to identify independent risk factors for platelet antibody positivity.

Results

The overall platelet antibody positivity rate was 7.68%. The positivity increased significantly with both a greater number of pregnancies and a history of miscarriage. Notably, thyroid diseases were strongly associated with platelet antibodies: women with thyroid diseases had a significantly higher positivity rate of 11.55%. Specifically, Hashimoto’s thyroiditis (HT) and thyroid nodules were identified as significant independent risk factors in the binary logistic regression analysis. Other significant independent risk factors included a history of blood transfusion, three or more pregnancies, three or more miscarriages, and thalassemia.

Conclusions

This study provides novel evidence of a significant association between maternal thyroid disorders (particularly HT and thyroid nodules) and a higher prevalence of platelet antibodies during pregnancy. These findings highlight the importance of considering thyroid status in antenatal care and suggest a potential benefit of proactive platelet antibody screening, especially in women with thyroid diseases, to help mitigate associated risks such as miscarriage and FNAIT.