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<p>To address the limitations of traditional silicone hydrogel contact lenses in wettability and drug release, an innovative approach was proposed by incorporating polyethylene glycol (PEG) and sodium hyaluronate (SH) into these lenses. Aminoalkyl-terminated polydimethylsiloxane (KF8010) was reacted with glycidyl methacrylate (GMA) to synthesize GKF8010, which was then mixed with methacryloxymethyltris (trimethylsiloxy) silane (TRIS), N,N-Dimethylaniline (DMA), and PEG400 to fabricate PEG-modified silicone hydrogel contact lenses (PEG-SCL) via UV molding. Unmodified lenses (SCL) were served as controls. The effects of PEG modification on lens properties, including water content, wettability, and optical clarity, and SH loading efficiency and drug release were evaluated. Additionally, the protein adsorption and biocompatibility of the lenses with human umbilical vein endothelial cells (HUVECs) were assessed. Results indicated that PEG-modified lenses exhibited superior water content, reduced protein adsorption, enhanced SH loading capacity and controlled release profiles, highlighting their potential for treating dry eye syndrome.</p>

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Preparation of Polyethylene Glycol-Modified Silicone Hydrogel Contact Lenses for Enhanced Sodium Hyaluronate Delivery

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Xiaojuan Zhang,
  • Zhao Wang,
  • Yao Zhou,
  • Caiyu Zhang,
  • Yu Li,
  • Changqing Zhang,
  • Yuan Zhao,
  • Qing Lin,
  • Wenli Song,
  • Dong Liang

摘要

To address the limitations of traditional silicone hydrogel contact lenses in wettability and drug release, an innovative approach was proposed by incorporating polyethylene glycol (PEG) and sodium hyaluronate (SH) into these lenses. Aminoalkyl-terminated polydimethylsiloxane (KF8010) was reacted with glycidyl methacrylate (GMA) to synthesize GKF8010, which was then mixed with methacryloxymethyltris (trimethylsiloxy) silane (TRIS), N,N-Dimethylaniline (DMA), and PEG400 to fabricate PEG-modified silicone hydrogel contact lenses (PEG-SCL) via UV molding. Unmodified lenses (SCL) were served as controls. The effects of PEG modification on lens properties, including water content, wettability, and optical clarity, and SH loading efficiency and drug release were evaluated. Additionally, the protein adsorption and biocompatibility of the lenses with human umbilical vein endothelial cells (HUVECs) were assessed. Results indicated that PEG-modified lenses exhibited superior water content, reduced protein adsorption, enhanced SH loading capacity and controlled release profiles, highlighting their potential for treating dry eye syndrome.