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<p>The hydrophobic sonosensitizer IR780 iodide (IR780) was loaded into liposomes to form Liposome@IR780 nanoparticles (NPs) for triple-negative breast cancer (TNBC) to enhance SDT via low-intensity ultrasound (LIU) irradiation. The NPs were characterized using various physicochemical methods including size distribution, zeta potential, and morphology. <i>In vitro</i> experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species (ROS) upon LIU irradiation. The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells. Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.</p>

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Liposome@IR780 Nanoparticles for Efficient Sonodynamic Therapy to Treat Triple-negative Breast Cancer

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Xiaozhu Zhong,
  • Cuiping Guo,
  • Jie Li,
  • Xian Shu,
  • Zhiwen Zeng,
  • Shan Yu,
  • Jiayi Zhou,
  • Ping Wang

摘要

The hydrophobic sonosensitizer IR780 iodide (IR780) was loaded into liposomes to form Liposome@IR780 nanoparticles (NPs) for triple-negative breast cancer (TNBC) to enhance SDT via low-intensity ultrasound (LIU) irradiation. The NPs were characterized using various physicochemical methods including size distribution, zeta potential, and morphology. In vitro experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species (ROS) upon LIU irradiation. The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells. Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.