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<p>The quantitative detection of lactic acid is crucial in medical diagnosis, sports medicine, and the food industry. Currently, non-enzymatic electrochemical lactate sensors have attracted significant attention for lactate detection owing to their high sensitivity, excellent chemical stability, low cost, and ease of miniaturization. Transition metal-based materials are extensively utilized in non-enzymatic electrochemical lactate sensors due to their superior electron transport properties, straightforward preparation processes, and cost-effectiveness. In this study, we present an enzyme-free electrochemical sensor platform based on indium tin oxide (ITO) and nickel hydroxide(Ni(OH)<sub>2</sub>) nanostructures, fabricated on an ITO substrate using a multiple potential step method. The resulting Ni(OH)<sub>2</sub>-ITO electrodes serve as an effective enzyme mimic, enhancing the electrocatalytic oxidation and detection of LA. The Ni(OH)<sub>2</sub> nanostructures synthesized from nickel chloride exhibit a well-defined redox peak, indicating high catalytic activity. The Ni(OH)<sub>2</sub>-ITO electrodes demonstrates superior electrocatalytic activity and sensing performance, characterized by a low positive potential (-0.47 V vs Ag/AgCl), a limit of detection (LOD) of 0.4038 μM (S/N = 3), a wide linear range from 0.0067 to 79.3966 mM (R<sup>2</sup> = 0.9923), and a sensitivity of 0.1325 mA·mM<sup>−1</sup>·cm<sup>−2</sup>. Additionally, the sensor exhibits excellent selectivity against common interference such as uric acid (UA), ascorbic acid (AA), Mg<sup>2+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup>. This work highlights the potential application of a robust alternative analytical tool for LA determination.</p>

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A novel nonenzymatic sensor of lactic acid based on nickel hydroxide nanostructure

  • 期刊论文

  • 发表日期：

    2025年4月30日

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  • Yuchun Li,
  • Ying Wu,
  • Chuyu Miao,
  • Yin Ma,
  • Siyao Rong,
  • Jiahao Guo,
  • Zhong Dai

摘要

The quantitative detection of lactic acid is crucial in medical diagnosis, sports medicine, and the food industry. Currently, non-enzymatic electrochemical lactate sensors have attracted significant attention for lactate detection owing to their high sensitivity, excellent chemical stability, low cost, and ease of miniaturization. Transition metal-based materials are extensively utilized in non-enzymatic electrochemical lactate sensors due to their superior electron transport properties, straightforward preparation processes, and cost-effectiveness. In this study, we present an enzyme-free electrochemical sensor platform based on indium tin oxide (ITO) and nickel hydroxide(Ni(OH)2) nanostructures, fabricated on an ITO substrate using a multiple potential step method. The resulting Ni(OH)2-ITO electrodes serve as an effective enzyme mimic, enhancing the electrocatalytic oxidation and detection of LA. The Ni(OH)2 nanostructures synthesized from nickel chloride exhibit a well-defined redox peak, indicating high catalytic activity. The Ni(OH)2-ITO electrodes demonstrates superior electrocatalytic activity and sensing performance, characterized by a low positive potential (-0.47 V vs Ag/AgCl), a limit of detection (LOD) of 0.4038 μM (S/N = 3), a wide linear range from 0.0067 to 79.3966 mM (R2 = 0.9923), and a sensitivity of 0.1325 mA·mM−1·cm−2. Additionally, the sensor exhibits excellent selectivity against common interference such as uric acid (UA), ascorbic acid (AA), Mg2+, Na+, and Ca2+. This work highlights the potential application of a robust alternative analytical tool for LA determination.