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<p>Due to an increased rate of mortality associated with the tumoral disease, the demand has driven pharmaceutical industries to focus on synthesizing the chemotherapeutic drug in precise concentrations and compositions to fulfill the needs and aid in disease treatment. Likewise, temozolomide (TMZ), an antitumor drug, has gained significant importance, and so its determination is very essential. The multi-walled carbon nanotubes and titanium carbide nanoparticles were used to prepare the carbon paste–modified sensor for the investigation of TMZ using voltammetric, surface, and electrochemical impedance spectroscopy (EIS) techniques. The surface properties were analyzed using SEM and EDX. The cyclic voltammetry studies showed that TMZ detection in a 0.2 M phosphate buffer solution gave two oxidation peaks and a reduction peak. Using the differential pulse voltammetric method, the limit of detection (LOD) was calculated within the linear range of 0.3 to 1.1 V as 1.64 × 10⁻⁷M and 5.2 × 10⁻⁸M for both oxidation peaks. Analytical electrochemical functions have been cleared by the reported sensor for the detection of TMZ in pharmaceutical formulations and real samples like human plasma, urine, and water samples.</p> Graphical Abstract <p></p>

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Electrochemical sensing of an anticancer drug temozolomide using carbon paste electrode enriched with porous carbon nanotubes and highly conductive titanium carbide

  • 期刊论文

  • 发表日期：

    2025年4月7日

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  • P. R. Kulkarni,
  • J. C. Abbar,
  • D. S. Lamani,
  • S. D. Lamani

摘要

Due to an increased rate of mortality associated with the tumoral disease, the demand has driven pharmaceutical industries to focus on synthesizing the chemotherapeutic drug in precise concentrations and compositions to fulfill the needs and aid in disease treatment. Likewise, temozolomide (TMZ), an antitumor drug, has gained significant importance, and so its determination is very essential. The multi-walled carbon nanotubes and titanium carbide nanoparticles were used to prepare the carbon paste–modified sensor for the investigation of TMZ using voltammetric, surface, and electrochemical impedance spectroscopy (EIS) techniques. The surface properties were analyzed using SEM and EDX. The cyclic voltammetry studies showed that TMZ detection in a 0.2 M phosphate buffer solution gave two oxidation peaks and a reduction peak. Using the differential pulse voltammetric method, the limit of detection (LOD) was calculated within the linear range of 0.3 to 1.1 V as 1.64 × 10⁻⁷M and 5.2 × 10⁻⁸M for both oxidation peaks. Analytical electrochemical functions have been cleared by the reported sensor for the detection of TMZ in pharmaceutical formulations and real samples like human plasma, urine, and water samples.

Graphical Abstract