<p>This paper introduces the concept of <i>neuroheuristics</i>—a novel transdisciplinary paradigm designed to advance cognitive neurodynamics by integrating insights from molecular biology, computing, behavioral science, and clinical neuroscience. Contrasted with the traditional reductionist approach rooted in classical determinism, neuroheuristics emphasizes a flexible, problem-solving methodology for investigating brain function across multiple levels of complexity. The paper explores the epistemological interplay among genetic, epigenetic, and environmental factors in brain development and pathology. The neuroheuristic framework aims to elucidate complex cognitive phenomena-such as memory, decision-making, and creativity-by bridging bottom-up and top-down research strategies. By incorporating contemporary technologies and recognizing the brain’s dynamic, nonlinear properties, neuroheuristics proposes a transformative shift in cognitive neurodynamics, enabling a deeper understanding of human cognition, disease mechanisms, and artificial intelligence. Its applicability is demonstrated through ongoing interdisciplinary research spanning neurophysiological disorders, computational modeling, and data-driven analytical techniques.</p>