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<p>The resistance of pathogenic <i>Candida</i> species to conventional antifungals has prompted the search for new molecules with antimicrobial activity. For this reason, the development of new compounds with antifungal activity is essential, for which the chemical modification of the structures of current antifungals, the repositioning of structures that have not been tested as antifungals, or the design of new molecules has been proposed. Among the strategies to obtain new antifungals in recent years, the synthesis of organometallic compounds has stood out, due to the potential shown against various pathogens. Among them, ferrocene stands out for its low toxicity and good stability, which has favored its application in the design of anticancer or antiparasitic agents. In addition, chemical molecules containing ferrocene are good candidates for possible use as antimicrobials. In order to evaluate whether a ferrocene-based chemical compound exhibits antifungal activity, the aim of the present work was to evaluate a ferrocenylselenoamide with activity against <i>Candida glabrata</i>, which exhibits innate azole resistance and is the species after <i>C. albicans</i> causing invasive candidiasis in immunocompromised patients. The compound showed inhibitory activity against <i>C. glabrata</i> and exhibited fungicidal behavior according to minimum fungicidal concentration (MFC) criteria. Cytotoxicity evaluation in murine fibroblasts (cell line L929) revealed a decrease in metabolic activity and loss of biomass, associated with depolymerization of actin filaments, without evidence of nuclear damage. Additionally, it was observed that the compound does not induce hemolysis at its minimum inhibitory concentration, although this effect appears at higher concentrations. Taken together, the results suggest that ferrocenylselenoamides have potential as antifungals according to microbiological criteria of loss viability but also demonstrate the need for further studies focused on their toxicological profile to support future therapeutic application.</p>

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Evaluation of the antifungal and cytotoxic activity of a repositioned chemical molecule against Candida glabrata

  • 期刊论文

  • 发表日期：

    2026年3月24日

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  • Edson E. Maqueda-Cabrera,
  • Lérida Liss Flores-Villavicencio,
  • Julio César Villagómez-Castro,
  • Mayra Cuéllar-Cruz

摘要

The resistance of pathogenic Candida species to conventional antifungals has prompted the search for new molecules with antimicrobial activity. For this reason, the development of new compounds with antifungal activity is essential, for which the chemical modification of the structures of current antifungals, the repositioning of structures that have not been tested as antifungals, or the design of new molecules has been proposed. Among the strategies to obtain new antifungals in recent years, the synthesis of organometallic compounds has stood out, due to the potential shown against various pathogens. Among them, ferrocene stands out for its low toxicity and good stability, which has favored its application in the design of anticancer or antiparasitic agents. In addition, chemical molecules containing ferrocene are good candidates for possible use as antimicrobials. In order to evaluate whether a ferrocene-based chemical compound exhibits antifungal activity, the aim of the present work was to evaluate a ferrocenylselenoamide with activity against Candida glabrata, which exhibits innate azole resistance and is the species after C. albicans causing invasive candidiasis in immunocompromised patients. The compound showed inhibitory activity against C. glabrata and exhibited fungicidal behavior according to minimum fungicidal concentration (MFC) criteria. Cytotoxicity evaluation in murine fibroblasts (cell line L929) revealed a decrease in metabolic activity and loss of biomass, associated with depolymerization of actin filaments, without evidence of nuclear damage. Additionally, it was observed that the compound does not induce hemolysis at its minimum inhibitory concentration, although this effect appears at higher concentrations. Taken together, the results suggest that ferrocenylselenoamides have potential as antifungals according to microbiological criteria of loss viability but also demonstrate the need for further studies focused on their toxicological profile to support future therapeutic application.