Scholarlink

<p>Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem disease with a wide range of symptoms. Many of its symptoms also occur in other diseases. ME/CFS is characterized by post-exertional malaise (PEM) and severe lack of strength and energy (fatigue). The aim of this study was to determine whether it is possible to distinguish between patients with ME/CFS and patients with ME/CFS-like symptoms among patients who are convinced that they have ME/CFS. As part of the APAV-ME/CFS survey, the data of 749 adults with a medical diagnosis of ME/CFS (DS1) were compared with those of 191 adult patients without a medical diagnosis who were convinced that they had ME/CFS (DS2). The DS2 patients were divided into two subgroups using a DSQ‑SF- and DSQ‑PEM-based screening test (Canadian Consensus Criteria [CCC] fulfilled&#xa0;=&#xa0;DS3; CCC not fulfilled&#xa0;=&#xa0;DS4). The descriptive evaluation was followed by a comparison of the different groups (Pearson χ<sup>2</sup> test, ANOVA with t‑test; <i>p</i> = 0.05, in the case of multiple answers Bonferroni correction to <i>p</i> = 0.003). In all, 51.6% of the DS2 patients fulfilled the central CCC characteristics (PEM, fatigue). DS3 and DS4 did not differ in terms of age, gender, duration of illness and other parameters. However, there were clear differences here between DS1 and DS3 and DS1 and DS4. DS1 and DS3 did not differ in terms of the frequency of typical ME/CFS symptoms, while there were significant differences between DS1 and DS4. Non-ME/CFS patients can thus be distinguished from ME/CFS patients using a few simplified questions based on the DSQ-SF and the DSQ-PEM. Since PEM and the specific form of fatigue are typical for ME/CFS, it is likely that the DS3 patients were suffering from ME/CFS. Doctors in routine care and with little experience in ME/CFS diagnostics could easily confirm their suspected diagnosis of ME/CFS. In addition, the screening instrument would be particularly suitable for diagnosing cognitively impaired patients due to its simplicity. In a next step, however, it would have to be validated in comparison to a reliable diagnosis by experts using the CCC.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Lassen sich mit einem einfachen, kurzen Screening-Test ME/CFS-Erkrankte (myalgische Enzephalomyelitis/chronisches Fatigue-Syndrom) von Patient:innen mit einer ME/CFS-ähnlichen Symptomatik unterscheiden?

  • 期刊论文

  • 发表日期：

    2025年4月3日

查看全文
  • Lotte Habermann-Horstmeier,
  • Lukas M. Horstmeier

摘要

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystem disease with a wide range of symptoms. Many of its symptoms also occur in other diseases. ME/CFS is characterized by post-exertional malaise (PEM) and severe lack of strength and energy (fatigue). The aim of this study was to determine whether it is possible to distinguish between patients with ME/CFS and patients with ME/CFS-like symptoms among patients who are convinced that they have ME/CFS. As part of the APAV-ME/CFS survey, the data of 749 adults with a medical diagnosis of ME/CFS (DS1) were compared with those of 191 adult patients without a medical diagnosis who were convinced that they had ME/CFS (DS2). The DS2 patients were divided into two subgroups using a DSQ‑SF- and DSQ‑PEM-based screening test (Canadian Consensus Criteria [CCC] fulfilled = DS3; CCC not fulfilled = DS4). The descriptive evaluation was followed by a comparison of the different groups (Pearson χ2 test, ANOVA with t‑test; p = 0.05, in the case of multiple answers Bonferroni correction to p = 0.003). In all, 51.6% of the DS2 patients fulfilled the central CCC characteristics (PEM, fatigue). DS3 and DS4 did not differ in terms of age, gender, duration of illness and other parameters. However, there were clear differences here between DS1 and DS3 and DS1 and DS4. DS1 and DS3 did not differ in terms of the frequency of typical ME/CFS symptoms, while there were significant differences between DS1 and DS4. Non-ME/CFS patients can thus be distinguished from ME/CFS patients using a few simplified questions based on the DSQ-SF and the DSQ-PEM. Since PEM and the specific form of fatigue are typical for ME/CFS, it is likely that the DS3 patients were suffering from ME/CFS. Doctors in routine care and with little experience in ME/CFS diagnostics could easily confirm their suspected diagnosis of ME/CFS. In addition, the screening instrument would be particularly suitable for diagnosing cognitively impaired patients due to its simplicity. In a next step, however, it would have to be validated in comparison to a reliable diagnosis by experts using the CCC.