Background and research question <p>Low health literacy (HL) is associated with poorer health, higher mortality, and higher utilisation of emergency services. It has, therefore, become an important topic in public health research. Previous studies suggest a&#xa0;social stratification of HL but have mostly only analysed differences in individual socioeconomic dimensions. This study aims to determine the role of interactions in such dimensions for low HL using data from the German survey GEDA2014/2015.</p> Study design and methods <p>Data from the cross-sectional survey “German Health Update 2014/2015” were analysed using logistic regression with interactions for the influence of sociodemographic variables on HL.</p> Results <p>Low and high age, low education, low income, low subjective social status, low social support, unemployment and the presence of multiple chronic diseases were associated with low HL. Migrants with low and medium education showed lower HL than nonmigrants of the same educational groups, while well-educated migrants showed higher HL than highly educated nonmigrants.</p> Conclusion <p>The identified interactions between social dimensions indicate more subtle social differences in HL than previously known. This can serve the development of needs-based interventions that could reach groups at high risk of low HL more precisely. At the same time, it shows the crucial role of education in HL.</p>