Scholarlink

Introduction <p>High-resolution computed tomography (HRCT) is essential for evaluating interstitial lung disease (ILD). The effect of slice thickness on threshold-based quantification of individual ILD components remains underexplored. This study investigates the effect of slice thickness on ILD quantification using Lung CT Analyzer.</p> Methods <p>Retrospective analysis of 53 ILD patients (mean age 64.3 ± 14.1&#xa0;years) who underwent chest CT scans with HRCT (slice thickness ≤ 1.25&#xa0;mm) and conventional CT (CCT, ≥ 2.5&#xa0;mm) reconstructions. Quantitative lung volumes, functional parenchyma, emphysema, ground-glass opacity (GGO), consolidation and affected parenchyma were assessed. The effects of contrast media (CM) application and ILD pattern was assessed separately.</p> Results <p>Emphysema volume was significantly higher in HRCT compared to CCT for the whole lung (766.9 ± 568.3&#xa0;mL vs. 482.6 ± 454.4&#xa0;mL, <i>p</i> &lt; 0.001), the right lung (431.4 ± 314.6&#xa0;mL vs. 270.2 ± 251.3&#xa0;mL, <i>p</i> &lt; 0.001), and the left lung (337.3 ± 259.9&#xa0;mL vs. 228.0 ± 221.5&#xa0;mL, <i>p</i> &lt; 0.001). Consolidation volumes also differed significantly between HRCT and CCT for the whole lung (271.6 ± 128.4&#xa0;mL vs. 252.0 ± 126.3&#xa0;mL, <i>p</i> &lt; 0.001), with similar findings for the right and left lung. Functional volume was underestimated in CCT reconstructions. No significant differences were observed for GGO volumes or overall affected parenchyma. CM application and ILD pattern had no significant interaction on the measurements.</p> Conclusion <p>Slice thickness significantly affects the quantification of functional parenchyma, emphysema and consolidation, whereas GGO and the overall ILD extent remain unaffected.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of slice thickness on quantitative analysis of interstitial lung disease: a retrospective volumetric chest CT study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月27日

查看全文
  • Marijan Pušeljić,
  • Borut Mohorko,
  • Tadej Počivavšek,
  • Florentine Moazedi-Fürst,
  • Johannes Schmid,
  • Michael Fuchsjäger,
  • Emina Talakić

摘要

Introduction

High-resolution computed tomography (HRCT) is essential for evaluating interstitial lung disease (ILD). The effect of slice thickness on threshold-based quantification of individual ILD components remains underexplored. This study investigates the effect of slice thickness on ILD quantification using Lung CT Analyzer.

Methods

Retrospective analysis of 53 ILD patients (mean age 64.3 ± 14.1 years) who underwent chest CT scans with HRCT (slice thickness ≤ 1.25 mm) and conventional CT (CCT, ≥ 2.5 mm) reconstructions. Quantitative lung volumes, functional parenchyma, emphysema, ground-glass opacity (GGO), consolidation and affected parenchyma were assessed. The effects of contrast media (CM) application and ILD pattern was assessed separately.

Results

Emphysema volume was significantly higher in HRCT compared to CCT for the whole lung (766.9 ± 568.3 mL vs. 482.6 ± 454.4 mL, p < 0.001), the right lung (431.4 ± 314.6 mL vs. 270.2 ± 251.3 mL, p < 0.001), and the left lung (337.3 ± 259.9 mL vs. 228.0 ± 221.5 mL, p < 0.001). Consolidation volumes also differed significantly between HRCT and CCT for the whole lung (271.6 ± 128.4 mL vs. 252.0 ± 126.3 mL, p < 0.001), with similar findings for the right and left lung. Functional volume was underestimated in CCT reconstructions. No significant differences were observed for GGO volumes or overall affected parenchyma. CM application and ILD pattern had no significant interaction on the measurements.

Conclusion

Slice thickness significantly affects the quantification of functional parenchyma, emphysema and consolidation, whereas GGO and the overall ILD extent remain unaffected.