Association between mpMRI detected tumor apparent diffusion coefficient and 5-year biochemical recurrence risk after radical prostatectomy

期刊论文
发表日期：

2024年7月16日

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Sarah Alessi,
Roberta Maggioni,
Stefano Luzzago,
Paul E. Summers,
Giuseppe Renne,
Fabio Zugni,
Maddalena Belmonte,
Sara Raimondi,
Silvano Vignati,
Francesco A. Mistretta,
Letizia Di Meglio,
Elisa D’Ascoli,
Alice Scarabelli,
Giulia Marvaso,
Ottavio De Cobelli,
Gennaro Musi,
Barbara Alicja Jereczek-Fossa,
Giuseppe Curigliano,
Giuseppe Petralia

摘要

Purpose

To assess the ability of tumor apparent diffusion coefficient (ADC) values obtained from multiparametric magnetic resonance imaging (mpMRI) to predict the risk of 5-year biochemical recurrence (BCR) after radical prostatectomy (RP).

Materials and methods

This retrospective analysis included 1207 peripheral and 232 non-peripheral zone prostate cancer (PCa) patients who underwent mpMRI before RP (2012–2015), with the outcome of interest being 5-year BCR. ADC was evaluated as a continuous variable and as categories: low (< 850 µm²/s), intermediate (850–1100 µm²/s), and high (> 1100 µm²/s). Kaplan–Meier curves with log-rank testing of BCR-free survival, multivariable Cox proportional hazard regression models were formed to estimate the risk of BCR.

Results

Among the 1439 males with median age 63 (± 7) years, the median follow-up was 59 months, and 306 (25%) patients experienced BCR. Peripheral zone PCa patients with BCR had lower tumor ADC values than those without BCR (874 versus 1025 µm²/s, p < 0.001). Five-year BCR-free survival rates were 52.3%, 74.4%, and 87% for patients in the low, intermediate, and high ADC value categories, respectively (p < 0.0001). Lower ADC was associated with BCR, both as continuously coded variable (HR: 5.35; p < 0.001) and as ADC categories (intermediate versus high ADC-HR: 1.56, p = 0.017; low vs. high ADC-HR; 2.36, p < 0.001). In the non-peripheral zone PCa patients, no association between ADC and BCR was observed.

Conclusion

Tumor ADC values and categories were found to be predictive of the 5-year BCR risk after RP in patients with peripheral zone PCa and may serve as a prognostic biomarker.