<p>Harmonic currents and voltages can cause a number of problems for electrical systems, including lower system performance, device and cable heat, and diminished functioning due to lost electromagnetic compatibility. Installation-generated harmonic currents move back to the system and spread as voltage harmonics, distorting the source signal, raising system loss, and decreasing component dependability. This research addresses the challenge of minimizing low-order harmonic components in cascaded H-Bridge multilevel inverters (CHB-MLI) used in solar photovoltaic (PV) systems. The study proposes a novel hybrid optimization technique, called Aquila-Chimp (AQ-CMP), which combines the strengths of Aquila optimization and chimp-inspired strategies to reduce Total Harmonic Distortion (THD). In optimizing and lowering the THD, the harmonics are separated by making an exceptional selection of switching angles and utilizing the Selective Harmonic Elimination (SHE) Pulse Width Modulation (PWM) method in conjunction with an integrated algorithm. The basic assumption is based on the estimations produced by the AQ-CMP, which is programmed using the best switching angles to provide a steady output and ensure that solar PV operates efficiently. The research is conducted in the MATLAB/Simulink software. The proposed method is demonstrated over a seven-level, nine-level, and eleven-level H-bridge inverter. The result of cascaded H-bridge inverters with seven, nine, and eleven levels using the proposed algorithm serves as justification for the proposed method. Accordingly, from the result, it is observed that the proposed AQ-CMP method possesses lower harmonics of (−0.0002) than the conventional methods when compared to other methods (0.0027), MPA (0.0020), CHO (−0.2811), and AQ-CMP (0.0012) for the 7^th order harmonics. The proposed method is useful in various applications such as high-voltage DC transmission, variable frequency drives, conveyors etc.</p>