COPD stage detection: leveraging the auto-metric graph neural network with inspiratory and expiratory chest CT images

Chronic obstructive pulmonary disease (COPD) is a common lung disease that can lead to restricted airflow and respiratory problems, causing a significant health, economic, and social burden. Detecting the COPD stage can provide a timely warning for prompt intervention in COPD patients. However, existing methods based on inspiratory (IN) and expiratory (EX) chest CT images are not sufficiently accurate and efficient in COPD stage detection. The lung region images are autonomously segmented from IN and EX chest CT images to extract the \(1,781\times 2\) $1,781\times 2$ lung radiomics and \(13,824\times 2\) $13,824\times 2$ 3D CNN features. Furthermore, a strategy for concatenating and selecting features was employed in COPD stage detection based on radiomics and 3D CNN features. Finally, we combine all the radiomics, 3D CNN features, and factor risks (age, gender, and smoking history) to detect the COPD stage based on the Auto-Metric Graph Neural Network (AMGNN). The AMGNN with radiomics and 3D CNN features achieves the best performance at 89.7 \(\%\) $\%$ of accuracy, 90.9 \(\%\) $\%$ of precision, 89.5 \(\%\) $\%$ of F1-score, and 95.8 \(\%\) $\%$ of AUC compared to six classic machine learning (ML) classifiers. Our proposed approach demonstrates high accuracy in detecting the stage of COPD using both IN and EX chest CT images. This method can potentially establish an efficient diagnostic tool for patients with COPD. Additionally, we have identified radiomics and 3D CNN as more appropriate biomarkers than Parametric Response Mapping (PRM). Moreover, our findings indicate that expiration yields better results than inspiration in detecting the stage of COPD.

The workflow of this study. (a) The IN and EX lung region is segmented using a well trained U Net (R231). (b) Radiomics features are obtained through the PyRadiomics tool, and 3D CNN features are extracted using the frozen encoder in the pre trained Med3D model. (c) The IN+EX radiomics and IN+EX 3D CNN features are concatenated, and the Lasso algorithm is subsequently applied to screen for useful data. (d) The selected features and ri sk factors are sent to the AMGNN, resulting in COPD multi classification outcomes.