<p>The 18-item Employee Well-Being Scale (Zheng et al., 2015) is widely used but time-intensive, highlighting the need for a brief, cross-culturally validated instrument that reliably captures its multidimensional nature. This study reports the development and validation of the 9-item Brief Employee Well-Being Scale (BEWBS) across six studies conducted in four Asian countries—Malaysia, India, China, and Indonesia—representing key contexts in the Global South. In Study 1, exploratory factor analysis identified nine items from the original scale while preserving its three-factor structure (life, work, and psychological well-being). Study 2 compared competing models in a Malaysian sample, establishing a superior second-order structure for the BEWBS. Study 3 validated the English version in India, replicating strong reliability, convergent, discriminant, and incremental validity. Study 4 extended validation to the Chinese version, demonstrating robust psychometric properties in Mandarin. Study 5 developed and tested the Indonesian version, further supporting the scale’s cross-linguistic and cultural applicability. Finally, Study 6 employed multi-group confirmatory factor analyses to establish measurement invariance across all four countries, enabling meaningful cross-national comparisons of employee well-being. Collectively, these studies provide rigorous evidence for the reliability, validity, and cross-cultural equivalence of the BEWBS across the English, Chinese, and Indonesian languages. The development of this short, culturally sensitive instrument contributes to inclusive well-being measurement in the Global South, responding to critiques of WEIRD-centric approaches. The BEWBS provides researchers, practitioners, and policymakers with an efficient and valid tool for advancing global understandings of employee well-being and for monitoring employee well-being in diverse economic and cultural contexts.</p>