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<p>This study examined 10-year trends (2010–2019) in major depressive episode (MDE), substance use disorder (SUD), and their co-occurrence among U.S. adolescents, and identified socio-ecological protective factors. Analyzing National Survey on Drug Use and Health data (<i>N</i> = 154,656), we employed joinpoint and multinomial logistic regression. Results revealed divergent trends: SUD alone rates declined (APC = − 10.0, <i>p</i> &lt; .001), while MDE alone increased significantly (APC = 11.6 for 2010–2015; 5.8 for 2015–2019, <i>p</i> &lt; .01). Critically, co-occurring MDE and SUD exhibited a significant upward inflection from 2016 to 2019 (APC = 9.4, <i>p</i> = .01). Parental monitoring, parental confidant, and religious salience were associated with decreased risks across all psychiatric phenotypes. Relative importance rankings of protective variables revealed that parental monitoring and parental confidant were the strongest protective factors across all outcomes, followed by religious salience and peer religiosity. Notably, involvement in school-based prevention education and problem-solving groups failed to mitigate the risk for co-occurring conditions. Findings necessitate shifting from siloed drug education to integrated, family-centered models that address the complex intersection of depression and substance use.</p>

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The Escalating Crisis of Comorbid Depression and Substance Use Disorders in US Adolescents: A 10-Year Trend Analysis (2010–2019)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月1日

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  • Daejun Park,
  • Sejung Yang,
  • Sehun Oh

摘要

This study examined 10-year trends (2010–2019) in major depressive episode (MDE), substance use disorder (SUD), and their co-occurrence among U.S. adolescents, and identified socio-ecological protective factors. Analyzing National Survey on Drug Use and Health data (N = 154,656), we employed joinpoint and multinomial logistic regression. Results revealed divergent trends: SUD alone rates declined (APC = − 10.0, p < .001), while MDE alone increased significantly (APC = 11.6 for 2010–2015; 5.8 for 2015–2019, p < .01). Critically, co-occurring MDE and SUD exhibited a significant upward inflection from 2016 to 2019 (APC = 9.4, p = .01). Parental monitoring, parental confidant, and religious salience were associated with decreased risks across all psychiatric phenotypes. Relative importance rankings of protective variables revealed that parental monitoring and parental confidant were the strongest protective factors across all outcomes, followed by religious salience and peer religiosity. Notably, involvement in school-based prevention education and problem-solving groups failed to mitigate the risk for co-occurring conditions. Findings necessitate shifting from siloed drug education to integrated, family-centered models that address the complex intersection of depression and substance use.