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<p>Substance use coping motives are a critical mechanism implicated in the co-occurrence of posttraumatic stress disorder (PTSD) and substance use disorders (SUD). This&#xa0;psychometric study employed latent profile analysis (LPA) to identify profiles of trauma-related substance use coping motives and examine how these distinct profiles predicted PTSD symptom severity, alcohol and drug use severity, functional impairment, polysubstance use, and usage of various substances. Trauma survivors (<i>N</i> = 284) in the United States with probable PTSD and SUD completed validated measures. LPA was applied to the Motives for Using Substances for Trauma Coping (MUST-Cope) Questionnaire subscales of cognitive-affective, physiological, sleep, and social motives. The LPA revealed an optimal four-profile solution: (1) Sleep Motives (28%), (2) Low Motives (40%), (3) Moderate Motives (20%), and (4) High Motives (12%). Post hoc pairwise comparisons across these extracted profiles evidenced significant differences on distal outcomes of PTSD severity, alcohol and drug use severity, functional impairment, polysubstance use, and differential rates of using specific substances, including cannabis, cocaine, stimulants, methamphetamine, inhalants, sedatives, hallucinogens, and street opioids. These findings underscore the heterogenous&#xa0;profile configurations for substance use coping motives among trauma survivors with a substance use disorder and offer insights for tailoring risk prevention programs and clinical interventions. Targeting riskier membership profiles of substance coping motives may reduce substance-related harm and enhance treatment outcomes.</p>

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A Latent Profile Analysis of Substance Use Coping Motives and Associations with Usage of Various Substances among Trauma Survivors with Comorbid PTSD and SUD

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Kelly E. Dixon,
  • Matthew T. Luciano,
  • Andrew Lac

摘要

Substance use coping motives are a critical mechanism implicated in the co-occurrence of posttraumatic stress disorder (PTSD) and substance use disorders (SUD). This psychometric study employed latent profile analysis (LPA) to identify profiles of trauma-related substance use coping motives and examine how these distinct profiles predicted PTSD symptom severity, alcohol and drug use severity, functional impairment, polysubstance use, and usage of various substances. Trauma survivors (N = 284) in the United States with probable PTSD and SUD completed validated measures. LPA was applied to the Motives for Using Substances for Trauma Coping (MUST-Cope) Questionnaire subscales of cognitive-affective, physiological, sleep, and social motives. The LPA revealed an optimal four-profile solution: (1) Sleep Motives (28%), (2) Low Motives (40%), (3) Moderate Motives (20%), and (4) High Motives (12%). Post hoc pairwise comparisons across these extracted profiles evidenced significant differences on distal outcomes of PTSD severity, alcohol and drug use severity, functional impairment, polysubstance use, and differential rates of using specific substances, including cannabis, cocaine, stimulants, methamphetamine, inhalants, sedatives, hallucinogens, and street opioids. These findings underscore the heterogenous profile configurations for substance use coping motives among trauma survivors with a substance use disorder and offer insights for tailoring risk prevention programs and clinical interventions. Targeting riskier membership profiles of substance coping motives may reduce substance-related harm and enhance treatment outcomes.