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<p>Substance use disorder relapse rates range from 40 to 86%, highlighting the need for effective interventions. Cognitive-behavioral therapy is widely used in the treatment of substance use disorders, but its time-based effectiveness remains unclear. This meta-analysis of 53 randomized controlled trials and quasi-experimental studies, including 5986 participants, assessed the effects of cognitive-behavioral therapy on relapse and resilience. Cognitive-behavioral therapy significantly reduced relapse compared to control conditions (standardized mean difference =  − 0.227, <i>p</i> = 0.001) and baseline (SMD =  − 0.678, <i>p</i> &lt; 0.001), and improved resilience compared to control conditions (SMD = 0.189, <i>p</i> = 0.047) and baseline (SMD = 0.825, <i>p</i> = 0.001). A nonlinear dose–response analysis revealed a sharp decline in relapse within 3&#xa0;months, followed by stabilization. Younger participants and university-based settings showed greater benefits. These findings support cognitive-behavioral therapy’s role in relapse prevention, emphasizing early intervention. Because the therapeutic gains of CBT tend to diminish over time, periodic booster or repeat sessions may be needed to maintain and reinforce long-term effectiveness.</p>

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Time-Based Effectiveness of Cognitive-Behavioral Therapy for Resilience and Relapse Prevention in Adults with Substance Use Disorder: A Multilevel Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年11月7日

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  • Ibraheem Mhaidat,
  • Mohammad Reza Taherian,
  • Seyed Saeed Hashemi Nazari,
  • Alireza Mosavi-Jarrahi,
  • Haniyeh Yeganeh,
  • Nabeel Al-Yateem,
  • Amina Al-Marzouqi,
  • Syed Azizur Rahman,
  • Zahir Vally

摘要

Substance use disorder relapse rates range from 40 to 86%, highlighting the need for effective interventions. Cognitive-behavioral therapy is widely used in the treatment of substance use disorders, but its time-based effectiveness remains unclear. This meta-analysis of 53 randomized controlled trials and quasi-experimental studies, including 5986 participants, assessed the effects of cognitive-behavioral therapy on relapse and resilience. Cognitive-behavioral therapy significantly reduced relapse compared to control conditions (standardized mean difference =  − 0.227, p = 0.001) and baseline (SMD =  − 0.678, p < 0.001), and improved resilience compared to control conditions (SMD = 0.189, p = 0.047) and baseline (SMD = 0.825, p = 0.001). A nonlinear dose–response analysis revealed a sharp decline in relapse within 3 months, followed by stabilization. Younger participants and university-based settings showed greater benefits. These findings support cognitive-behavioral therapy’s role in relapse prevention, emphasizing early intervention. Because the therapeutic gains of CBT tend to diminish over time, periodic booster or repeat sessions may be needed to maintain and reinforce long-term effectiveness.