<p>Cryptocurrency speculation involves investing in assets with highly volatile price movements in which large sums can be gained or lost in short periods. Although fear of missing out (FOMO) has been positively linked to this type of activity, less is known about the role of regret, such as how people react to actions taken (acts of commission) or not taken (acts of omission). Anticipated regret was investigated in a study involving 403 investors (<i>M</i> = 325, <i>F</i> = 73, Other = 5) recruited from an online panel and presented with meme coin scenarios that manipulated omission (not buying) or commission (sold early) while also examining the roles of social comparison and temporal framing. Scenarios were arranged in a 2 × 2 × 2 factorial design with FOMO, risk tolerance, impulsivity, financial literacy and problem gambling included as covariates to control for potential individual differences. Acts of commission were associated with greater regret and negative emotion but not with FOMO-based investment decisions. No effects were found for temporal distance or social comparison. At-risk and problem-gambling investors were also found to be more vulnerable to negative emotions and risky intention decision-making than non-risk gamblers. FOMO and risk tolerance were related to making decisions based on FOMO, whereas cryptocurrency literacy appeared to mitigate this tendency. These findings underscore the potential value of consumer education in raising awareness of psychological biases that are likely to lead to riskier speculative decisions.&#xa0;</p>