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<p>There has been increasing discussion regarding the legalization of hallucinogens in recent years. However, literature remains limited on the associations of hallucinogen use with prescription drug misuse and illicit drug use. This study aimed to address this knowledge gap by analyzing data from the 2021–2022 National Survey on Drug Use and Health, focusing on adults aged 18&#xa0;years and older (unweighted <i>n</i> = 90,503). The primary independent variable was hallucinogen use status (never, lifetime, or past 12&#xa0;months), and the outcomes included prescription drug misuse (pain relievers, tranquilizers, or stimulants) and illicit drug use (cocaine, crack, inhalants, heroin, or methamphetamine). A series of logistic regression models were conducted. In the final sample, 14.77% of respondents reported lifetime hallucinogen use, and 4.11% reported past 12-month use. Additionally, 10.99% reported prescription drug misuse, and 3.66% reported illicit drug use in the past 12&#xa0;months. Regression analysis showed that, compared to those who had never used hallucinogens, participants reporting use in the past 12&#xa0;months had significantly higher odds of prescription drug misuse (AOR = 1.43, 99% CI: 1.36, 1.50) and illicit drug use (AOR = 1.64, 99% CI: 1.57, 1.72) in the past 12&#xa0;months. Given that recent hallucinogen use was associated with significantly higher odds of both prescription drug misuse and illicit drug use, policymakers and public health practitioners should consider hallucinogen use, particularly past-year use, as a potential indicator of broader substance misuse risks.</p>

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Hallucinogen Use and Associated Illicit Drug Use and Prescription Drug Misuse Among Adults in the USA: Results from a National Survey

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • Yen-Han Lee,
  • Stephan Arndt,
  • Christopher Joji,
  • Hannah Fleischer,
  • Mack Shelley,
  • Ching-Ti Liu,
  • Yen-Chang Chang

摘要

There has been increasing discussion regarding the legalization of hallucinogens in recent years. However, literature remains limited on the associations of hallucinogen use with prescription drug misuse and illicit drug use. This study aimed to address this knowledge gap by analyzing data from the 2021–2022 National Survey on Drug Use and Health, focusing on adults aged 18 years and older (unweighted n = 90,503). The primary independent variable was hallucinogen use status (never, lifetime, or past 12 months), and the outcomes included prescription drug misuse (pain relievers, tranquilizers, or stimulants) and illicit drug use (cocaine, crack, inhalants, heroin, or methamphetamine). A series of logistic regression models were conducted. In the final sample, 14.77% of respondents reported lifetime hallucinogen use, and 4.11% reported past 12-month use. Additionally, 10.99% reported prescription drug misuse, and 3.66% reported illicit drug use in the past 12 months. Regression analysis showed that, compared to those who had never used hallucinogens, participants reporting use in the past 12 months had significantly higher odds of prescription drug misuse (AOR = 1.43, 99% CI: 1.36, 1.50) and illicit drug use (AOR = 1.64, 99% CI: 1.57, 1.72) in the past 12 months. Given that recent hallucinogen use was associated with significantly higher odds of both prescription drug misuse and illicit drug use, policymakers and public health practitioners should consider hallucinogen use, particularly past-year use, as a potential indicator of broader substance misuse risks.