<p>Cashing in on the first-ever opportunity for data release after the legalization of marijuana in 2018, the present research brings criminological theories to explore the correlation of cannabis use among Indigenous peoples in Canada. Logistic regression of a subsample of all Indigenous peoples in General Social Survey data shows that variables broadly derived from general strain model, together with those of the comorbid model and social support model, can explain the variance of cannabis use among Indigenous peoples. Lived experiences of discrimination and cyber victimization, residential mobility, and mental health are significant correlates of marijuana use. Policies that aim to increase equity and equality, as promised in the 1982 Canadian Charter of Rights and Freedoms, would alleviate the dilemma of Indigenous peoples and are thus called for.</p>