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<p>Many individuals with a substance use disorder (SUD) also experience polysubstance use (PSU), yet research often focuses on single substance use. Further, investigating sex differences is vital, as males and females may exhibit distinct substance use patterns, impacting treatment outcomes. This study employs a network analytic approach to examine sex differences in symptom patterns and interrelationships in PSU, analyzing data from 792 participants using two or more substances. The study evaluates symptoms of alcohol use disorder (AUD), cannabis use disorder (CUD), and drug use disorder (DUD). Results reveal distinct network structures for males and females. Network comparison tests indicate significant differences in specific connections between symptoms for males and females. In this sample, females’ polysubstance use was more strongly associated with more severe SUD symptoms. Conclusions emphasize the need for interventions that address sex-specific vulnerabilities, enhancing the effectiveness of prevention and treatment strategies in managing PSU. Understanding these differences is crucial for developing tailored approaches to support individuals facing SUD.</p>

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Sex Differences in Polysubstance Use Symptoms: A Network Analysis

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Eli Farmer,
  • Polly Ingram,
  • Peter Finn

摘要

Many individuals with a substance use disorder (SUD) also experience polysubstance use (PSU), yet research often focuses on single substance use. Further, investigating sex differences is vital, as males and females may exhibit distinct substance use patterns, impacting treatment outcomes. This study employs a network analytic approach to examine sex differences in symptom patterns and interrelationships in PSU, analyzing data from 792 participants using two or more substances. The study evaluates symptoms of alcohol use disorder (AUD), cannabis use disorder (CUD), and drug use disorder (DUD). Results reveal distinct network structures for males and females. Network comparison tests indicate significant differences in specific connections between symptoms for males and females. In this sample, females’ polysubstance use was more strongly associated with more severe SUD symptoms. Conclusions emphasize the need for interventions that address sex-specific vulnerabilities, enhancing the effectiveness of prevention and treatment strategies in managing PSU. Understanding these differences is crucial for developing tailored approaches to support individuals facing SUD.