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<p>Cancer poses a serious threat to human health due to its difficulty in prevention and high incidence rate. Traditional detection technologies struggle to achieve real-time and high-sensitivity detection. Differences in refractive index between normal and cancer cells, arising from varying protein content, enable the identification of cancer cells by analyzing shifts in the fiber loss curve. Therefore, this paper proposes a D-shaped photonic crystal fiber biosensor based on surface plasmon resonance for identifying cancer cells within normal cells. A chemically stable gold film coating is applied to extend the sensor’s lifespan. Finite element analysis optimized the sensor’s microchannel radius, gold nanolayer thickness, and large air hole radius to achieve optimal sensing performance. Within the refractive index detection range of 1.360–1.392, maximum wavelength sensitivity reached 10,000&#xa0;nm/RIU. The sensor can detect multiple types of cancer cells, including skin cancer, blood cancer and cervical cancer, with average sensitivities of 6750&#xa0;nm/RIU, 5000&#xa0;nm/RIU, and 5208.33&#xa0;nm/RIU, and quality factors of 319.60 RIU⁻¹, 252.53 RIU⁻¹, and 234.82 RIU⁻¹, respectively. The detection limit for cancer cell detection can reach as low as 1.48 × 10⁻⁵ RIU. The sensor features high sensitivity, a wide detection range, high quality factor, and low detection limit, achieving high-precision detection of micro-refractive index changes. It possesses potential application value in bioanalysis and medical diagnostics.</p>

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High-Performance D-Shaped Optical Fiber Biosensor for Detection of Cancerous Cells Based on Surface Plasmon Resonance

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Minghui Huo,
  • Xiaokang Wang,
  • Pengxiao Xu,
  • Jingchao Bao,
  • Aolin Hou,
  • Yage Zhao,
  • Xiaojian Meng,
  • Kun Yu,
  • Yufang Liu

摘要

Cancer poses a serious threat to human health due to its difficulty in prevention and high incidence rate. Traditional detection technologies struggle to achieve real-time and high-sensitivity detection. Differences in refractive index between normal and cancer cells, arising from varying protein content, enable the identification of cancer cells by analyzing shifts in the fiber loss curve. Therefore, this paper proposes a D-shaped photonic crystal fiber biosensor based on surface plasmon resonance for identifying cancer cells within normal cells. A chemically stable gold film coating is applied to extend the sensor’s lifespan. Finite element analysis optimized the sensor’s microchannel radius, gold nanolayer thickness, and large air hole radius to achieve optimal sensing performance. Within the refractive index detection range of 1.360–1.392, maximum wavelength sensitivity reached 10,000 nm/RIU. The sensor can detect multiple types of cancer cells, including skin cancer, blood cancer and cervical cancer, with average sensitivities of 6750 nm/RIU, 5000 nm/RIU, and 5208.33 nm/RIU, and quality factors of 319.60 RIU⁻¹, 252.53 RIU⁻¹, and 234.82 RIU⁻¹, respectively. The detection limit for cancer cell detection can reach as low as 1.48 × 10⁻⁵ RIU. The sensor features high sensitivity, a wide detection range, high quality factor, and low detection limit, achieving high-precision detection of micro-refractive index changes. It possesses potential application value in bioanalysis and medical diagnostics.