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<p>The development of multifunctional nanomaterials with enhanced optical and antimicrobial properties is crucial for next-generation biomedical applications. Hybrid metal–semiconductor nanostructures, particularly ZnO/Au nanohybrids, offer synergistic plasmonic effects that can boost both functionalities. Here, ZnO/Au nanohybrids were synthesized via a sustainable two-step process using <i>Diospyros lotus</i> peel extract and systematically characterized. XRD confirmed hexagonal ZnO and fcc Au phases, while TEM revealed quasi-spherical particles (35–55&#xa0;nm) with moderate colloidal stability. The incorporation of Au domains induced localized surface plasmon resonance, enhancing optical responses. Antibacterial testing against six bacterial strains showed that ZnO/Au nanohybrids had markedly lower minimum inhibitory concentrations (MIC) compared with ZnO alone, with the most pronounced effects against Gram-negative bacteria (e.g., 157.5&#xa0;µg/mL for <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i>). These results, along with significant cytotoxicity toward Nalm-6 leukemia cells (87.6% mortality at 250&#xa0;µg/mL), underscore the dual plasmonic-biological potential of ZnO/Au nanohybrids for biosensing, photomedicine, and antimicrobial strategies.</p>

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Plasmonic ZnO/Au Nanohybrids: Sustainable Synthesis, Structural Features, and Dual Bioactivity

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • Shaymaa Abdulaali Mukheef,
  • Saleem H. Trier,
  • Ali Abbasi,
  • Danya Awni Kamal,
  • Mohammed Hadi Shinen,
  • Shaymaa Awad Kadhim,
  • Masoomeh Sadat Fini,
  • Kamran Heydaryan

摘要

The development of multifunctional nanomaterials with enhanced optical and antimicrobial properties is crucial for next-generation biomedical applications. Hybrid metal–semiconductor nanostructures, particularly ZnO/Au nanohybrids, offer synergistic plasmonic effects that can boost both functionalities. Here, ZnO/Au nanohybrids were synthesized via a sustainable two-step process using Diospyros lotus peel extract and systematically characterized. XRD confirmed hexagonal ZnO and fcc Au phases, while TEM revealed quasi-spherical particles (35–55 nm) with moderate colloidal stability. The incorporation of Au domains induced localized surface plasmon resonance, enhancing optical responses. Antibacterial testing against six bacterial strains showed that ZnO/Au nanohybrids had markedly lower minimum inhibitory concentrations (MIC) compared with ZnO alone, with the most pronounced effects against Gram-negative bacteria (e.g., 157.5 µg/mL for Pseudomonas aeruginosa and Klebsiella pneumoniae). These results, along with significant cytotoxicity toward Nalm-6 leukemia cells (87.6% mortality at 250 µg/mL), underscore the dual plasmonic-biological potential of ZnO/Au nanohybrids for biosensing, photomedicine, and antimicrobial strategies.