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<p>The current study analyzes and proposes a strontium titanium (SrTiO<sub>3</sub>/STO)–based SPR biosensor with different layer configurations including several 2D materials such as graphene, black phosphorus (BP), and hexagonal boron nitride (h-BN). The said 2D nanomaterials are examined individually over the STO layer following the improvement of the STO thickness to 12&#xa0;nm upon the gold-coated SPR structure. The study reports the highest sensitivity ever recorded, 433&#xa0;Deg/RIU for the optimized structure Prism (BK7)/Au (50&#xa0;nm)/SrTiO<sub>3</sub>(12&#xa0;nm)/BP(01 layer)/urine sample for similar sensor configurations. For urine glucose refractive indices (RI), the scope is 1.335, 1.336, 1.337, 1.338,&#xa0;1.341, and 1.347 for a corresponding glucose concentration of 0&#xa0;g/dl, 0.625&#xa0;g/dl, 1.25&#xa0;g/dl, 2.5&#xa0;g/dl, 5&#xa0;g/dl, and 10&#xa0;g/dl. Electric field distributions were obtained for individual 2D material layers. Numerical calculations are also performed for other explored detecting efficiency metrics, like detection accuracy (DA), quality factor (QF), and limit of detection (LOD), which are of 0.151 Deg <sup>−1</sup>, 65.38 RIU<sup>−</sup><sup>1</sup>, and 1.25e-5, respectively. The proposed structure’s potential as an effective label-free biosensor is demonstrated by comparing it to related published works.</p>

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Design and Analysis of SrTiO₃-Enhanced SPR Biosensor for Improved Sensitivity in Non-invasive Glucose Sensing

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Sandipta Senapati,
  • Archana Yadav,
  • Madhusudan Mishra

摘要

The current study analyzes and proposes a strontium titanium (SrTiO3/STO)–based SPR biosensor with different layer configurations including several 2D materials such as graphene, black phosphorus (BP), and hexagonal boron nitride (h-BN). The said 2D nanomaterials are examined individually over the STO layer following the improvement of the STO thickness to 12 nm upon the gold-coated SPR structure. The study reports the highest sensitivity ever recorded, 433 Deg/RIU for the optimized structure Prism (BK7)/Au (50 nm)/SrTiO3(12 nm)/BP(01 layer)/urine sample for similar sensor configurations. For urine glucose refractive indices (RI), the scope is 1.335, 1.336, 1.337, 1.338, 1.341, and 1.347 for a corresponding glucose concentration of 0 g/dl, 0.625 g/dl, 1.25 g/dl, 2.5 g/dl, 5 g/dl, and 10 g/dl. Electric field distributions were obtained for individual 2D material layers. Numerical calculations are also performed for other explored detecting efficiency metrics, like detection accuracy (DA), quality factor (QF), and limit of detection (LOD), which are of 0.151 Deg −1, 65.38 RIU−1, and 1.25e-5, respectively. The proposed structure’s potential as an effective label-free biosensor is demonstrated by comparing it to related published works.