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<p>This study presents a facile method for biosensing uric acid using a reduced graphene oxide-gold (rGO-Au) nanocomposite. Uric acid serves as a crucial biomarker for various pathological conditions, including gout, metabolic syndrome, type-2 diabetes, kidney malfunctions and cardiovascular diseases. Therefore, facile techniques for monitoring uric acid in blood serum levels (2–10&#xa0;mg/dL) are in demand. Here, we demonstrate uric acid sensing with a detection limit of 2&#xa0;mg/dL and a sensitivity of 1&#xa0;mg/dL. The synthesised graphene oxide (GO), gold nanoparticles (AuNPs), and the rGO-Au nanocomposite were studied using UV–visible spectroscopy, varying the levels of uric acid (1 to 20&#xa0;mg/dL). Our findings reveal that the uric acid exhibits significantly higher UV–visible absorbance (five times) when combined with rGO-Au nanocomposite. The enhancement is attributed to the synergistic effect of surface plasmon resonance (SPR) and the unique properties of the nanocomposite. This work provides valuable insights into designing highly sensitive and cost-effective uric acid biosensors with potential applications in clinical diagnostics and health monitoring.</p>

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Serum Level Biosensing of Uric Acid Using RGO-Au Nanocomposite Based On UV–Vis Spectroscopy

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Aruna Unnikrishnan,
  • Libu K. Alexander

摘要

This study presents a facile method for biosensing uric acid using a reduced graphene oxide-gold (rGO-Au) nanocomposite. Uric acid serves as a crucial biomarker for various pathological conditions, including gout, metabolic syndrome, type-2 diabetes, kidney malfunctions and cardiovascular diseases. Therefore, facile techniques for monitoring uric acid in blood serum levels (2–10 mg/dL) are in demand. Here, we demonstrate uric acid sensing with a detection limit of 2 mg/dL and a sensitivity of 1 mg/dL. The synthesised graphene oxide (GO), gold nanoparticles (AuNPs), and the rGO-Au nanocomposite were studied using UV–visible spectroscopy, varying the levels of uric acid (1 to 20 mg/dL). Our findings reveal that the uric acid exhibits significantly higher UV–visible absorbance (five times) when combined with rGO-Au nanocomposite. The enhancement is attributed to the synergistic effect of surface plasmon resonance (SPR) and the unique properties of the nanocomposite. This work provides valuable insights into designing highly sensitive and cost-effective uric acid biosensors with potential applications in clinical diagnostics and health monitoring.