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<p>Breast cancer, a prevalent malignancy worldwide, necessitates the development of highly sensitive and specific diagnostic tools for early detection and personalized treatment. Biomarkers include routine or ordinary, novel, and potential biomolecules consisting of nucleic acids (DNA/RNA), key proteins, genes, and intact cells. Advances in biotechnology and molecular medicine have led to the identification of biomarkers for early diagnosis and therapeutic intervention, particularly through the development of novel biosensors, which hold significant clinical value. In this review article, we first present the main biomarkers involved in breast cancer. Then, the mechanism and different types of SPR techniques including traditional SPR, growth-mediated SPR, etching, and SPR imaging technologies are introduced. Furthermore, we explore various localized SPR (LSPR) biosensor designs, surface functionalization strategies, and signal transduction methods used for breast cancer biomarker detection. This review specifically mentions LSPR sensor designs, surface functionalization strategies, and signal transduction methods, indicating a focus on specific and innovative approaches within the SPR technology. We examine the performance characteristics of these biosensors, including their detection limits and selectivity, and discuss their potential for clinical translation.</p> Graphical Abstract <p></p>

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Molecular Recognition of Breast Cancer Biomarkers via Localized Surface Plasmon Resonance Method

  • 期刊论文

  • 发表日期：

    2025年5月31日

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  • Faride Ranjbari,
  • Yasamin Pahlavan,
  • Masoud Khalifezadeh,
  • Mehdi Fathi,
  • Seyed Hossein Khaleghinejad,
  • Hamideh Imanzadeh,
  • Maryam Saberi,
  • Farzaneh Fathi

摘要

Breast cancer, a prevalent malignancy worldwide, necessitates the development of highly sensitive and specific diagnostic tools for early detection and personalized treatment. Biomarkers include routine or ordinary, novel, and potential biomolecules consisting of nucleic acids (DNA/RNA), key proteins, genes, and intact cells. Advances in biotechnology and molecular medicine have led to the identification of biomarkers for early diagnosis and therapeutic intervention, particularly through the development of novel biosensors, which hold significant clinical value. In this review article, we first present the main biomarkers involved in breast cancer. Then, the mechanism and different types of SPR techniques including traditional SPR, growth-mediated SPR, etching, and SPR imaging technologies are introduced. Furthermore, we explore various localized SPR (LSPR) biosensor designs, surface functionalization strategies, and signal transduction methods used for breast cancer biomarker detection. This review specifically mentions LSPR sensor designs, surface functionalization strategies, and signal transduction methods, indicating a focus on specific and innovative approaches within the SPR technology. We examine the performance characteristics of these biosensors, including their detection limits and selectivity, and discuss their potential for clinical translation.

Graphical Abstract