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<p>A novel photonic crystal fiber (PCF) with a minimalistic design featuring only four air holes is proposed for the early detection of cancer cells. To enhance the sensing capabilities, the surface plasmon resonance (SPR) phenomenon is intentionally incorporated, enabling high-performance and label-free detection. The sensor structure is designed with a reduced number of air holes, which not only simplifies the fabrication process but also minimizes structural complexity. Besides that, open channel methodology is utilized that simplifies the analyte filling and cleaning process. Moreover, for sensor longevity, chemically stable gold is considered. As an additional layer, TiO<sub>2</sub> is used that increases adhesion between silica and gold. However, sensors perform exceptionally well for total six classes of cancer cell. The wavelength sensitivity (Ws) is recorded up to 7857.14&#xa0;nm/RIU with FOM of 130.95 in case of MCF-7 cell. Additionally, amplitude sensitivity (AS) and resolution are recorded of 436.73 RIU<sup>‒1</sup> and 1.27 × 10<sup>‒5</sup> RIU, respectively. Hence, high performance and simple structure make this sensor suitable in biosensing field especially in early detection of different classes of cancer cell.</p>

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High-Performance Optical Fiber Biosensor for Early Cancer Cell Identification

  • 期刊论文

  • 发表日期：

    2025年5月10日

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  • Abdulkarem H. M. Almawgani,
  • Md. Aslam Mollah,
  • Yousif S. Adam,
  • Hussein S. Gumaih,
  • Monir Abdullah

摘要

A novel photonic crystal fiber (PCF) with a minimalistic design featuring only four air holes is proposed for the early detection of cancer cells. To enhance the sensing capabilities, the surface plasmon resonance (SPR) phenomenon is intentionally incorporated, enabling high-performance and label-free detection. The sensor structure is designed with a reduced number of air holes, which not only simplifies the fabrication process but also minimizes structural complexity. Besides that, open channel methodology is utilized that simplifies the analyte filling and cleaning process. Moreover, for sensor longevity, chemically stable gold is considered. As an additional layer, TiO2 is used that increases adhesion between silica and gold. However, sensors perform exceptionally well for total six classes of cancer cell. The wavelength sensitivity (Ws) is recorded up to 7857.14 nm/RIU with FOM of 130.95 in case of MCF-7 cell. Additionally, amplitude sensitivity (AS) and resolution are recorded of 436.73 RIU‒1 and 1.27 × 10‒5 RIU, respectively. Hence, high performance and simple structure make this sensor suitable in biosensing field especially in early detection of different classes of cancer cell.