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<p>Carcinoembryonic antigen (CEA) plays a crucial role in the diagnosis and monitoring of various cancers, including liver, breast, and colorectal cancers. Elevated CEA levels in human serum are strongly correlated with these malignancies, emphasizing the need for accurate CEA measurement in cancer detection and management. This study presents a novel surface plasmon resonance (SPR) biosensor, leveraging 2D materials and a Kretschmann configuration, for sensitive CEA detection. The sensor’s multilayer structure consists of a BK7 prism, silver (Ag), graphene, zinc oxide (ZnO), and molybdenum disulfide (MoS<sub>2</sub>), which together enhance its performance in aqueous environments. Using the finite difference time domain (FDTD) numerical method, the sensor’s sensitivity and key parameters were analyzed. At a wavelength of 633&#xa0;nm, the sensor achieved a sensitivity of 153.75&#xa0;deg/RIU and a figure of merit (FOM) of 23.56 RIU<sup>−1</sup>, outperforming previous designs. Comparative studies demonstrated the superior sensitivity of this SPR sensor, making it a promising tool for biosensing applications, medical diagnostics, food safety, and environmental monitoring. This research underscores the potential of SPR technology for rapid, accurate CEA detection, contributing to improved cancer diagnostics and patient management.&#xa0;</p>

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Enhanced Surface Plasmon Resonance Biosensor for Carcinoembryonic Antigen Detection Using 2D Materials (Graphene and MoS2) in a Kretschmann Configuration

  • 期刊论文

  • 发表日期：

    2025年5月9日

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  • Ali Khodaie,
  • Hamid Heidarzadeh

摘要

Carcinoembryonic antigen (CEA) plays a crucial role in the diagnosis and monitoring of various cancers, including liver, breast, and colorectal cancers. Elevated CEA levels in human serum are strongly correlated with these malignancies, emphasizing the need for accurate CEA measurement in cancer detection and management. This study presents a novel surface plasmon resonance (SPR) biosensor, leveraging 2D materials and a Kretschmann configuration, for sensitive CEA detection. The sensor’s multilayer structure consists of a BK7 prism, silver (Ag), graphene, zinc oxide (ZnO), and molybdenum disulfide (MoS2), which together enhance its performance in aqueous environments. Using the finite difference time domain (FDTD) numerical method, the sensor’s sensitivity and key parameters were analyzed. At a wavelength of 633 nm, the sensor achieved a sensitivity of 153.75 deg/RIU and a figure of merit (FOM) of 23.56 RIU−1, outperforming previous designs. Comparative studies demonstrated the superior sensitivity of this SPR sensor, making it a promising tool for biosensing applications, medical diagnostics, food safety, and environmental monitoring. This research underscores the potential of SPR technology for rapid, accurate CEA detection, contributing to improved cancer diagnostics and patient management.