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<p>The D-shape optical fiber biosensor based on surface plasmon resonance (SPR) has been investigated in this work for the detection of human cancerous liver tissues. The hexagonal boron nitride h-BN/perovskite CH<sub>3</sub>NH<sub>3</sub>PbCl<sub>3</sub>/gold hybrid nanostructure-based SPR biosensor operating in visible to near-infrared wavelengths region has been theoretically studied to enhance the sensor sensitivity and to overcome the low penetration depth (PD) of the electric field encountered in conventional biosensors. The integration of perovskite materials to the biosensor aims to develop more cost-effective and highly sensitive devices and the elaboration of CH<sub>3</sub>NH<sub>3</sub>PbCl<sub>3</sub>/h-BN hybrid structure aims to obtain strong stability and biocompatibility. To achieve maximum wavelength sensitivity, the sensor’s structural properties were numerically studied and optimized using the finite element approach. The simulation results showed a maximum wavelength sensitivity of 7200 nm/RIU throughout a wide refractive index range (RI) of 1.22 to 1.39, with a maximum resolution of 1.39 × 10<sup>−5</sup> RIU. Additionally, the analysis revealed that the investigated sensor achieves a notably high penetration depth of 370 nm, surpassing the PD of conventional SPR senor. The penetration depth enhancement highlights the sensor’s potential for highly precise RI sensing, making it a good contender for numerous biomedical applications. Due to higher sensitivity and penetration depth, the studied sensor has been used to identify healthy and cancerous liver human tissues (normal (N), metastatic (MET), and hepatocellular carcinoma (HCC)) through the evaluation of their respective refractive index values.</p>

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Numerical Investigation of Highly Sensitive SPR Sensor Using Perovskite/Hexagonal Boron Nitride as a Nano Dielectric Layers for Human Liver Cancer Detection

  • 期刊论文

  • 发表日期：

    2025年4月16日

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  • Roqiya Belmerabet,
  • Azzedine Bellel,
  • Salah Sahli

摘要

The D-shape optical fiber biosensor based on surface plasmon resonance (SPR) has been investigated in this work for the detection of human cancerous liver tissues. The hexagonal boron nitride h-BN/perovskite CH3NH3PbCl3/gold hybrid nanostructure-based SPR biosensor operating in visible to near-infrared wavelengths region has been theoretically studied to enhance the sensor sensitivity and to overcome the low penetration depth (PD) of the electric field encountered in conventional biosensors. The integration of perovskite materials to the biosensor aims to develop more cost-effective and highly sensitive devices and the elaboration of CH3NH3PbCl3/h-BN hybrid structure aims to obtain strong stability and biocompatibility. To achieve maximum wavelength sensitivity, the sensor’s structural properties were numerically studied and optimized using the finite element approach. The simulation results showed a maximum wavelength sensitivity of 7200 nm/RIU throughout a wide refractive index range (RI) of 1.22 to 1.39, with a maximum resolution of 1.39 × 10−5 RIU. Additionally, the analysis revealed that the investigated sensor achieves a notably high penetration depth of 370 nm, surpassing the PD of conventional SPR senor. The penetration depth enhancement highlights the sensor’s potential for highly precise RI sensing, making it a good contender for numerous biomedical applications. Due to higher sensitivity and penetration depth, the studied sensor has been used to identify healthy and cancerous liver human tissues (normal (N), metastatic (MET), and hepatocellular carcinoma (HCC)) through the evaluation of their respective refractive index values.