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<p>Cancer is one of the major threats to the normal healthy living of people. Breast and cervical cancers have been reported to be of major concern, especially for women. Early diagnosis and timely treatment are essential for effective cure and survival. Optical sensors based on surface plasmon resonance (SPR) are best suited for the accurate detection of cancers in real-time. Three hybrid nano-structured SPR sensor configurations viz. Au/ZnO/MXene, Ag/ZnO/MXene, and Cu/ZnO/MXene, suitable for the detection of breast and cervical cancers, have been proposed, and the performance parameters have been analyzed with Matlab. Higher sensitivities of 12,200&#xa0;nm/RIU, 13,200&#xa0;nm/RIU, and 12,800&#xa0;nm/RIU, respectively, have been observed for breast cancer type-I, breast cancer type-II, and cervical cancers. The proposed sensors perform well over a wide range of refractive index values and can serve as versatile biosensors for different types of cancers<b>.</b></p> Graphical Abstract <p></p>

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Hybrid Nano-Structured SPR Biosensors: a Novel Approach to Breast and Cervical Cancer Detection

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • Seena R,
  • Shiny Paul,
  • Sudheer VR

摘要

Cancer is one of the major threats to the normal healthy living of people. Breast and cervical cancers have been reported to be of major concern, especially for women. Early diagnosis and timely treatment are essential for effective cure and survival. Optical sensors based on surface plasmon resonance (SPR) are best suited for the accurate detection of cancers in real-time. Three hybrid nano-structured SPR sensor configurations viz. Au/ZnO/MXene, Ag/ZnO/MXene, and Cu/ZnO/MXene, suitable for the detection of breast and cervical cancers, have been proposed, and the performance parameters have been analyzed with Matlab. Higher sensitivities of 12,200 nm/RIU, 13,200 nm/RIU, and 12,800 nm/RIU, respectively, have been observed for breast cancer type-I, breast cancer type-II, and cervical cancers. The proposed sensors perform well over a wide range of refractive index values and can serve as versatile biosensors for different types of cancers.

Graphical Abstract