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<p>The present study investigated the efficacy of eco-friendly bimetallic nanoparticles (BM NPs) in eradicating microorganisms. BM NPs were synthesized with a safe, cost-effective, and environmentally friendly physical approach. Several modern analytic methods were employed to characterize the BMNPs in this study to ensure thorough structural and morphological investigation. Zeta potential analysis assessed the surface charge’s stability and evaluated crystallinity. HR-TEM was used to analyze the size and distribution of the particles. The particle size distribution was homogeneous, ranging from 10 to 30&#xa0;nm, indicating homogeneity in the nanoparticles’ physical nature. The agar diffusion technique assessed BM NP’s efficacy in eradicating bacteria such as <i>Streptococcus mutans</i> and <i>Klebsiella pneumoniae</i>. The results demonstrated a statistically significant decrease in bacterial cell proliferation (<i>P</i> &lt; 0.001) compared to the untreated controls. CuO/FeO and their bimetallic combination, BM NPs, were the most effective in bacterial eradication. The inhibitory zones measured 20&#xa0;mm for <i>S. mutans</i> and 16&#xa0;mm for <i>K. pneumoniae</i>, their dimensions being more significant than that of the inhibitory zone seen with single-metal nanoparticles. The excellent antibacterial efficiency of the BM NPs underlines their potential as effective antimicrobial agents. These findings highlight the possible impact of BM NPs on the pharmaceutical and biomedical fields by offering new avenues for treating bacterial infections.</p>

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Synergistic Effect of Bimetallic Nanoparticles and Evaluation as an Antibacterial Agent Against Streptococcus mutans and Klebsiella pneumonia

  • 期刊论文

  • 发表日期：

    2025年2月6日

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  • Laith A. Yaaqoob,
  • Aiyah S. Noori,
  • Hassan Lafta Atiyah,
  • Uday M. Nayef,
  • Nisreen Kh. Abdalameer

摘要

The present study investigated the efficacy of eco-friendly bimetallic nanoparticles (BM NPs) in eradicating microorganisms. BM NPs were synthesized with a safe, cost-effective, and environmentally friendly physical approach. Several modern analytic methods were employed to characterize the BMNPs in this study to ensure thorough structural and morphological investigation. Zeta potential analysis assessed the surface charge’s stability and evaluated crystallinity. HR-TEM was used to analyze the size and distribution of the particles. The particle size distribution was homogeneous, ranging from 10 to 30 nm, indicating homogeneity in the nanoparticles’ physical nature. The agar diffusion technique assessed BM NP’s efficacy in eradicating bacteria such as Streptococcus mutans and Klebsiella pneumoniae. The results demonstrated a statistically significant decrease in bacterial cell proliferation (P < 0.001) compared to the untreated controls. CuO/FeO and their bimetallic combination, BM NPs, were the most effective in bacterial eradication. The inhibitory zones measured 20 mm for S. mutans and 16 mm for K. pneumoniae, their dimensions being more significant than that of the inhibitory zone seen with single-metal nanoparticles. The excellent antibacterial efficiency of the BM NPs underlines their potential as effective antimicrobial agents. These findings highlight the possible impact of BM NPs on the pharmaceutical and biomedical fields by offering new avenues for treating bacterial infections.