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<p>A prism-based surface plasmon resonance (SPR) sensor for the detection of colorectal cancer (CRC) is presented. We suggest a novel layered SPR design to enhance the figure of merit (FOM) and the other sensing characteristics at a wavelength of 1000&#xa0;nm. The sensor design consists of a calcium fluoride prism (CaF<sub>2</sub>), silver (Ag), beryllium hexa-aluminate (BHA), and bovine serum albumin (BSA) heterojunction. BHA acquires high optical density and a low extinction coefficient, which is crucial for sensitive detection in biosensors. The thickness of Ag (thickness <i>d</i><sub>1</sub>) and BHA (thickness <i>d</i><sub>2</sub>) is effectively coordinated to obtain optimized FOM under optimum radiation damping (ORD), keeping the thickness of BSA constant at 3.5&#xa0;nm. The attained high value of FOM is 6855.56 RIU<sup>−1</sup> at <i>d</i><sub>1</sub> = 48&#xa0;nm, corresponding to <i>d</i><sub>2</sub> = 8.7&#xa0;nm by the 2D simulation approach. The attained value of the power loss ratio (PLR) is 1.8 and the field enhancement factor (FEF) is 1.10. The product of FOM, PLR, and FEF, which is also known as the combined performance factor (CPF), is obtained to be 13,578 RIU<sup>−1</sup>. In addition, with the ORD condition, the suggested use of BHA leads to significantly optimized sensing efficiency, and it has been examined for the first time to the best of our knowledge.</p>

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Performance Evaluation of Prism-Based SPR Biosensor for Detection of Colorectal Cancer Under Radiation Damping: Seeking High Figure-of-Merit

  • 期刊论文

  • 发表日期：

    2025年2月10日

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  • Kajal Singh,
  • Adarsh Chandra Mishra,
  • Sudhir Shukla,
  • Pooja Lohia,
  • D. K. Dwivedi,
  • Gaber E. Eldesoky,
  • M. Khalid Hossain

摘要

A prism-based surface plasmon resonance (SPR) sensor for the detection of colorectal cancer (CRC) is presented. We suggest a novel layered SPR design to enhance the figure of merit (FOM) and the other sensing characteristics at a wavelength of 1000 nm. The sensor design consists of a calcium fluoride prism (CaF2), silver (Ag), beryllium hexa-aluminate (BHA), and bovine serum albumin (BSA) heterojunction. BHA acquires high optical density and a low extinction coefficient, which is crucial for sensitive detection in biosensors. The thickness of Ag (thickness d1) and BHA (thickness d2) is effectively coordinated to obtain optimized FOM under optimum radiation damping (ORD), keeping the thickness of BSA constant at 3.5 nm. The attained high value of FOM is 6855.56 RIU−1 at d1 = 48 nm, corresponding to d2 = 8.7 nm by the 2D simulation approach. The attained value of the power loss ratio (PLR) is 1.8 and the field enhancement factor (FEF) is 1.10. The product of FOM, PLR, and FEF, which is also known as the combined performance factor (CPF), is obtained to be 13,578 RIU−1. In addition, with the ORD condition, the suggested use of BHA leads to significantly optimized sensing efficiency, and it has been examined for the first time to the best of our knowledge.