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<p>In the past few years, there has been a significant focus on the utilization of copper oxide in the field of biological applications, due to its low toxicity and biocompatibility. Pure, Zn-doped, and Zn/Co–co-doping CuO cauliflowers with large surface area were created using hydrothermal technique with varying Co condensation (1%, 2%, and 3%), along with a constant Zn concentration. The structural, surface morphology, and optical characteristics of pure, Zn-doped, and Zn/Co co-doped copper oxide were investigated. The incorporation of Zn and Co into copper oxide was found to have a notable impact on the size of the crystallite, lattice parameters, and the sample band gap energies. XRD analysis revealed a covellite monoclinic polycrystalline form featuring a (<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11468_2024_2649_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="21" /> </InlineMediaObject> <EquationSource Format="TEX">\({1}^{-}\)</EquationSource> <EquationSource Format="MATHML"><math> <msup> <mrow> <mn>1</mn> </mrow> <mo>-</mo> </msup> </math></EquationSource> </InlineEquation> 11) favored direction across all samples. FE-SEM examination confirmed the formation of CuO nanoparticles displaying a cauliflower-shaped hierarchical structure. Optical measurements yielded principles of the optical gap falling within the range of 2.58–1.67&#xa0;eV. The antimicrobial efficacy of pure CuO, Zn-doped CuO, and Zn/Co co-doped CuO against <i>S. aureus</i> and<i> E. coli</i> strains was evaluated through inhibition zone assays. While all samples displayed notable antibacterial properties, the 3% Zn/3% Co co-doping CuO exhibited the strongest antibacterial activity, with a maximum inhibitory concentration of 12&#xa0;mg/ml, against both gram-positive and gram-negative microorganisms. Furthermore, the antibacterial activity showed that the inhibition zone of Zn/Co co-doped CuO was 13–19&#xa0;mm for <i>E. coli</i> and 15–20&#xa0;mm for <i>S. aureus</i> at a high concentration of Fe dopant.</p>

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Antibacterial Activity of Undoped and (Zn, Co) Co-Doped CuO Nanostructure Prepared by Hydrothermal Technique

  • 期刊论文

  • 发表日期：

    2025年1月31日

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  • Ali Khudair Abbas,
  • Selma M. H. AL-Jawad,
  • Natheer Jamal Imran

摘要

In the past few years, there has been a significant focus on the utilization of copper oxide in the field of biological applications, due to its low toxicity and biocompatibility. Pure, Zn-doped, and Zn/Co–co-doping CuO cauliflowers with large surface area were created using hydrothermal technique with varying Co condensation (1%, 2%, and 3%), along with a constant Zn concentration. The structural, surface morphology, and optical characteristics of pure, Zn-doped, and Zn/Co co-doped copper oxide were investigated. The incorporation of Zn and Co into copper oxide was found to have a notable impact on the size of the crystallite, lattice parameters, and the sample band gap energies. XRD analysis revealed a covellite monoclinic polycrystalline form featuring a ( \({1}^{-}\) 1 - 11) favored direction across all samples. FE-SEM examination confirmed the formation of CuO nanoparticles displaying a cauliflower-shaped hierarchical structure. Optical measurements yielded principles of the optical gap falling within the range of 2.58–1.67 eV. The antimicrobial efficacy of pure CuO, Zn-doped CuO, and Zn/Co co-doped CuO against S. aureus and E. coli strains was evaluated through inhibition zone assays. While all samples displayed notable antibacterial properties, the 3% Zn/3% Co co-doping CuO exhibited the strongest antibacterial activity, with a maximum inhibitory concentration of 12 mg/ml, against both gram-positive and gram-negative microorganisms. Furthermore, the antibacterial activity showed that the inhibition zone of Zn/Co co-doped CuO was 13–19 mm for E. coli and 15–20 mm for S. aureus at a high concentration of Fe dopant.