Detection of Skin, Cervical, and Breast Cancer Using Au–Ag Alloy and WS₂-Based Surface Plasmon Resonance Sensor

Surface plasmon resonance (SPR) is used in this article to introduce a novel multilayer configuration and investigate its efficacy as a cancer detection sensor. Our proposed structure comprises an analyte-containing sensing layer underneath an alloy (Au–Ag) and a WS₂ layer on top. Utilizing angle interrogation for analysis and a BK7 prism set up in the Kretschmann configuration, SPR is induced. Sellmeier equations are utilized to compute reflectivity and additional parameters of the multilayer design. According to our analysis, the maximum sensitivity of 304°/RIU was achieved with alloy metal and 2*WS₂ layered SPR sensor configuration, which is significantly higher than recent SPR-based sensors at 662-nm wavelength. The proposed sensor measured the refractive index (RI) of the sensing medium (SM) at 1.399, which is a tiny change, and found a penetration depth (PD) of 189.79 nm. The proposed sensor performance parameters for various cancer types, including skin, cervical, and breast cancers, have been examined. The proposed SPR sensor shows a high potential for accurately detecting different biomolecules, as evidenced by the 39.33/RIU FoM achieved at 1.399 RI of SM with 37 nm thickness of alloy metal layer.