The recent transport measurements of La3Ni2O7 uncovered a “right-triangle” shape of the superconducting dome in the pressure-temperature (P-T) phase diagram. Motivated by this, we perform theoretical first-principles studies of La3Ni2O7 with the pressure ranging from 0 to 100 GPa. Notably, we reveal a pressure dependence of the \(\text{Ni-}d_{\,z^{2}}\) electron density at the Fermi energy ( \(n_{z}^{E_{\rm{F}}}\) ) that highly coincides with such shape. On this basis, we further explore the electronic structure under uniaxial stress. By tracking the stress response of \(n_{z}^{E_{\rm{F}}}\) , we propose that superconductivity can be achieved by applying only ⋃2 GPa of compression along the c axis. The idea is further exemplified from the perspectives of lattice distortion, band structure, Fermi surface and superconducting phase coherence. We also discuss the possible charge modulation under the stress and provide an insight into the relation between \(n_{z}^{E_{\rm{F}}}\) and the superconducting Tc in La3Ni2O7 system. Our study provides new routes to the search of high-Tc superconductors in future experiments.
