<p>Flexible sensors have garnered significant interest for applications in wearable electronics and aerospace monitoring. However, achieving highly sensitive and stable multi-parameter sensing on a single platform remains a key challenge due to material integration complexity and signal decoupling. In this study, we present a flexible ion-electronic wireless pressure-temperature sensor (IEPTS) capable of simultaneously detecting pressure and temperature with high performance. The sensor features a broad pressure sensing range (0–150 kPa) and high sensitivity (931.46 kPa⁻¹), enabled by a carbon nanotube-based ionic network that forms an ion-electron co-conduction pathway. It also provides accurate temperature sensing over a wide range (10°C–94°C) with excellent linearity (up to 99.8%). By integrating two materials with opposite temperature coefficients of resistance, thermal interference in pressure signals is reduced by a factor of four. The IEPTS can be conformally attached to the human throat to detect subtle glottal movements and temperature variations, enabling accurate speech recognition with 92.98% accuracy. Furthermore, it demonstrates robust dynamic performance in wind tunnel experiments, effectively tracking variations in airflow and temperature at different angles of attack. This dual-mode flexible sensor offers a promising platform for advanced applications in voice interaction, physiological monitoring, and intelligent aerospace systems.</p>