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<p>Postoperative abdominal adhesion represents a frequent clinical challenge. Despite the numerous direct and indirect approaches developed to address this issue, standalone physical or chemical strategies exhibit inherent limitations and often fail to achieve optimal antiadhesion outcomes. In this study, an injectable, biodegradable hydrogel incorporating micelles formed through Schiff base cross-linking between lauric acid-modified carboxymethyl chitosan (CMCS-LA) and oxidized hyaluronic acid (OHA) is presented as an efficient physical-chemical combined antiadhesion solution. The hydrogel demonstrates rapid gelation, tunable stiffness, biodegradability, injectability, and outstanding self-healing properties. Serving as an adherent physical barrier on abdominal tissues prevents abnormal tissue attachment. The release of the hydrophobic drug honokiol, which is physically encapsulated in CMCS-LA micelles, is sustained to activate peritoneal mesothelial cells, thereby reducing postoperative adhesion formation after surgery. In a rat model of lateral wall defects and caecal abrasion, the hydrogel effectively suppressed abnormal fibrous tissue hyperplasia and inflammatory responses while preventing adhesion. This dual-function system successfully integrates physical barrier properties with chemical activity, offering a promising approach for future antiadhesion therapies.</p>

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Injectable biodegradable and micelle-incorporated dynamic adhesive hydrogels with sustained honokiol release for postoperative antiadhesion via the combination of a physical barrier and peritoneal mesothelial cell activation

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Yunhua Wu,
  • Shaowen Zhuo,
  • Zhixing Zhang,
  • Ruizhi Zhao,
  • Dong Liu,
  • Bei Lin,
  • Mengting Shi,
  • Baolin Guo,
  • Xin Zhao

摘要

Postoperative abdominal adhesion represents a frequent clinical challenge. Despite the numerous direct and indirect approaches developed to address this issue, standalone physical or chemical strategies exhibit inherent limitations and often fail to achieve optimal antiadhesion outcomes. In this study, an injectable, biodegradable hydrogel incorporating micelles formed through Schiff base cross-linking between lauric acid-modified carboxymethyl chitosan (CMCS-LA) and oxidized hyaluronic acid (OHA) is presented as an efficient physical-chemical combined antiadhesion solution. The hydrogel demonstrates rapid gelation, tunable stiffness, biodegradability, injectability, and outstanding self-healing properties. Serving as an adherent physical barrier on abdominal tissues prevents abnormal tissue attachment. The release of the hydrophobic drug honokiol, which is physically encapsulated in CMCS-LA micelles, is sustained to activate peritoneal mesothelial cells, thereby reducing postoperative adhesion formation after surgery. In a rat model of lateral wall defects and caecal abrasion, the hydrogel effectively suppressed abnormal fibrous tissue hyperplasia and inflammatory responses while preventing adhesion. This dual-function system successfully integrates physical barrier properties with chemical activity, offering a promising approach for future antiadhesion therapies.