<p>The isolated hybrid AC/DC multi-energy microgrid (IH-MEMG) offers an effective solution for meeting the electrical, heating, and cooling energy demands of remote and off-grid areas. For an IH-MEMG, system transient dynamics (i.e., frequency or voltage of the electricity network) and economics are critical aspects that pose the greatest concern to operators. However, these aspects are generally investigated separately owing to their different time scales. To integrate these aspects from the scope of real-time control, this study proposes a bi-layer coordinated power regulation strategy considering system dynamics and economics for the IH-MEMG. First, coupling relationships among multiple sub-networks are analyzed, and a frequency-voltage coupling model between the AC and DC sides is established. Then, a bi-layer coordinated power regulation strategy is developed for the IH-MEMG with output characteristics of different components involved: the primary layer includes a multi-entity power support mechanism used to improve the dynamics of the electricity network, wherein a cooperation principle of the combined cooling, heating, and power (CCHP) unit and energy storage unit (ESU) is designed in detailed; meanwhile, the secondary layer includes a real-time economics-oriented optimization framework used to adjust the power references of multiple units generated from the primary layer for cost efficiency improvement (notably, the primary layer can work independently). Finally, the effectiveness of the proposed strategy is verified through comprehensive simulations under varying operation scenarios.</p>