<p>The Yalu River metallogenic belt in eastern Liaoning and Jilin is one of the most important gold and polymetallic provinces in the eastern North China Craton. The Yalu River fault zone controls the distribution of Mesozoic magmatic rocks, volcanic-sedimentary basins, and gold and polymetallic deposits. The widespread development of Mesozoic gold deposits is the main metallogenic feature, and the gold mineralization is genetically related to deep processes of destruction of the North China Craton. The gold deposits are controlled by the multi-order structural systems of the Yalu River fault zone. The first-order structures constrain the distribution of metallogenic belt, the composite positions of the second-order structures and first-order structures control the occurrence of ore fields, and the third-order to lower-order structures control the localization of individual deposits and orebodies. With further detailed research on the relationship between tectonic evolution and mineralization, coupled with sustained exploration efforts, significant breakthroughs have been achieved in the exploration of altered-rock–type gold deposits along the fault zone, such as the recently discovered large to super-large Qiuguobi and Gangcaodianzi altered-rock–type gold deposits. The identification of extensive auriferous alteration zones, characterized by intensive silicification and pyritization, highlights the immense prospecting potential of the Yalu River fault zone. Notably, the Qiuguobi, Gumaling, Daguling, Wulong-Yangjia, and Gangcaodianzi mining areas are identified as prime targets for future gold exploration breakthroughs in eastern Liaoning and Jilin provinces.</p>