<p>This study summarizes recent research findings on the regional tectonic evolution and metallogenic mechanisms in the East Tianshan Tectonic Belt, proposing a Paleozoic episodic metallogenic model for the region. During the Paleozoic, the East Tianshan tectonic belt experienced multiple changes in subduction angles and polarities, which resulted in six arc-basin transition processes and multiple periods of mineralization in approximately 200 m.y.: (1) the Kanggur oceanic crust northward subduction forming the Harlik and Dananhu-Tousuquan island arcs and related porphyry deposits in the Late Ordovician, (2) opening of the Kalatage back-arc basin in the Harlik and Dananhu-Tousuquan island arcs and related VMS deposits in the Early to Middle Silurian, (3) closure of the Kalatage back-arc basin and related porphyry-epithermal deposits in the Late Silurian, (4) extension of the Harlik and Dananhu-Tousuquan island arcs, along with the closure of shallow marine basins, forming porphyry deposits in the Late Devonian, (4) bidirectional subduction of the Kanggur oceanic plate in the Early Carboniferous forming the Yamansu continental margin arc and related basins with submarine volcanic-type Fe deposits in the south and porphyry deposits in the north; (5) closure of the Yamansu continental margin basin and related Fe-Cu deposits in the Late Carboniferous, and (6) collision between the Yamansu continental margin arc and the Dananhu island arc, followed by extension, forming orogenic Au deposits and following magmatic Cu-Ni sulfide deposits in the Early Permian. These findings help to establish a precise framework for the Paleozoic tectonic evolution and metallogenic processes in the East Tianshan tectonic belt, which has important implications for further categorizing the multi-stage metallogenic events in the Central Asian Orogenic Belt. Additionally, they also provide a scientific basis for more accurate metallogenic predictions in the East Tianshan tectonic belt.</p>