<p>To accurately evaluate the Antarctic Ice Sheet (AIS) mass change rate and its spatiotemporal characteristics, we derive the AIS mass change series from April 2002 to December 2023 using an improved point-mass model approach with data-driven regularization matrices and iteratively determined multiple regularization parameters. Then, we analyze the spatio-temporal characteristics of the mass change rate over the AIS, focusing on four glacier basins in the Wilkes Land-Queen Mary Land (WL-QML) region of the East AIS (EAIS), namely the Denman, Moscow, Totten, and Vincennes Bay glacier basins. The results indicate that the AIS contribution to GMSL (global mean sea level) rise peaked at 5.99±0.43 mm in February 2020, followed by a mass gain period lasting over three years, ultimately resulting in a total GMSL contribution of 5.10±0.52 mm by the end of 2023. Moreover, the AIS experienced substantial mass loss during the 2011–2020 period, with a rate of 142.06±56.12 Gt a⁻¹, mainly due to intensified mass loss in the West AIS and the WL-QML region of the EAIS. Further analysis shows that the mass loss rate of the four glacier basins in the WL-QML region during the 2011–2020 period increased by 47.64±8.14 Gt a⁻¹ compared with the 2002–2010 period, with expanded areas of mass loss spreading inland. Notably, the Vincennes Bay and Denman glacier basins transitioned from mass balance and accumulation to intense mass loss, respectively. An in-depth investigation reveals that the increased ice discharge and decreased SMB (surface mass balance) contribute 27.47% and 72.53%, respectively, to the intensified mass loss of the four glacier basins. Overall, the study presents the mass change characteristics of the AIS over the past 22 years, highlights the instability of four important glacier basins in the EAIS, and provides valuable scientific insights for related polar research.</p>