Scholarlink

<p>Radiotherapy-induced osteoradionecrosis of the jaw (ORNJ) affects quality of life by causing severe pain, persistent infections, and stomatognathic dysfunction. Current ORNJ treatments are limited by several factors, including surgical trauma and notable individual differences. Oxidative stress, which is a critical driver of radiation-induced injury, promotes inflammation and disrupts the balance between bone formation and resorption. Here, we developed ceria-doped silicate nanozymes (CeSNs) to eliminate reactive oxygen species (ROS) by inducing a superoxide dismutase-like (SOD-like) and catalase-like (CAT-like) cascade. ROS-eliminating mitophagy contributed to the restoration of jawbone radiation injury. Dl-3-n-butylphthalide (NBP) encapsulated in CeSNs (NBP@CeSNs) demonstrated improved pH-responsive release for enhanced angiogenesis, while the silicon ions of silicate enhanced jawbone osteogenesis, thus providing the nanozymes with angiogenesis and osteogenesis capabilities. Our NBP@CeSNs nanozymes provided a promising pathway for ORNJ treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mitophagy activation for jawbone radiation injury therapy via angiogenesis/osteogenesis-active nanozymes

  • 期刊论文

  • 发表日期：

    2026年4月9日

查看全文
  • Tianxiao Wang,
  • Weihua Shao,
  • Ting Zhou,
  • Yuchao Li,
  • Ran Qin,
  • Ziyu Chen,
  • Jikang Cao,
  • Xinyu Hu,
  • Jingxuan Cang,
  • Chang Sun,
  • Yuli Wang,
  • Huijun Jiang,
  • Feng Han,
  • Yongchu Pan,
  • Hua Yuan,
  • Jiandong Jiang,
  • Fan Wu

摘要

Radiotherapy-induced osteoradionecrosis of the jaw (ORNJ) affects quality of life by causing severe pain, persistent infections, and stomatognathic dysfunction. Current ORNJ treatments are limited by several factors, including surgical trauma and notable individual differences. Oxidative stress, which is a critical driver of radiation-induced injury, promotes inflammation and disrupts the balance between bone formation and resorption. Here, we developed ceria-doped silicate nanozymes (CeSNs) to eliminate reactive oxygen species (ROS) by inducing a superoxide dismutase-like (SOD-like) and catalase-like (CAT-like) cascade. ROS-eliminating mitophagy contributed to the restoration of jawbone radiation injury. Dl-3-n-butylphthalide (NBP) encapsulated in CeSNs (NBP@CeSNs) demonstrated improved pH-responsive release for enhanced angiogenesis, while the silicon ions of silicate enhanced jawbone osteogenesis, thus providing the nanozymes with angiogenesis and osteogenesis capabilities. Our NBP@CeSNs nanozymes provided a promising pathway for ORNJ treatment.