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<p>The maturation of the gastrointestinal tract and its interconnected microbial consortia in various ruminant species is essential for their survival and productivity, as this symbiotic group plays a key role in metabolizing phyto-derived feeds into bioavailable nutrients. The rumen mucosa serves as a crucial conduit for complex host-microbiota interplay, while scarce knowledge is available regarding their co-oscillation patterns from birth to puberty. Here, we characterized th overall interaction of five age groups, from 1-day-old to 90-day-old goats. The findings indicated that the composition of the mucosa-attached microbiota underwent significant changes, with <i>Mannheimia</i>, <i>Porphyromonas</i> and <i>Streptococcus</i> taking the lead as the dominant genera at day 1, <i>Akkermansia muciniphila</i> and <i>Lactobacillus amylovorus</i> dominated at day 10, and a mature microbiota characterized by <i>Succiniclasticum ruminis</i>, <i>Ruminococcus albus</i>, <i>Succinivibrio dextrinosolvens</i>, and <i>Fibrobacter succinogenes</i> until day 90. Additionally, the rumen mucosa underwent a three-phase temporal shift during early life, from digestive system to immune development, and finally to nutrient metabolism. Furthermore, the integration of mucosal microbiome and host gene expression profiles uncovered a phase-specific interaction between the microbial community and host epithelium, with the early phase emphasizing digestive and immune development and the later phase focusing on enhanced nutrient metabolism. Collectively, microbiome-host co-oscillation in the rumen mucosa shaped the ruminal ecosystem during early life.</p>

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Microbiome-host co-oscillation patterns in shaping ruminal ecosystem from birth to puberty in a goat model

  • 期刊论文

  • 发表日期：

    2025年8月19日

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  • Jian Wu,
  • Xiaoli Zhang,
  • Zhiliang Tan,
  • Jinzhen Jiao,
  • Chuanshe Zhou

摘要

The maturation of the gastrointestinal tract and its interconnected microbial consortia in various ruminant species is essential for their survival and productivity, as this symbiotic group plays a key role in metabolizing phyto-derived feeds into bioavailable nutrients. The rumen mucosa serves as a crucial conduit for complex host-microbiota interplay, while scarce knowledge is available regarding their co-oscillation patterns from birth to puberty. Here, we characterized th overall interaction of five age groups, from 1-day-old to 90-day-old goats. The findings indicated that the composition of the mucosa-attached microbiota underwent significant changes, with Mannheimia, Porphyromonas and Streptococcus taking the lead as the dominant genera at day 1, Akkermansia muciniphila and Lactobacillus amylovorus dominated at day 10, and a mature microbiota characterized by Succiniclasticum ruminis, Ruminococcus albus, Succinivibrio dextrinosolvens, and Fibrobacter succinogenes until day 90. Additionally, the rumen mucosa underwent a three-phase temporal shift during early life, from digestive system to immune development, and finally to nutrient metabolism. Furthermore, the integration of mucosal microbiome and host gene expression profiles uncovered a phase-specific interaction between the microbial community and host epithelium, with the early phase emphasizing digestive and immune development and the later phase focusing on enhanced nutrient metabolism. Collectively, microbiome-host co-oscillation in the rumen mucosa shaped the ruminal ecosystem during early life.