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<p>Microplastics (MPs) are considered one of the main causes of male and female infertility. However, the reproductive toxicity and its related mechanisms are currently understood primarily through animal models with acute exposure to MPs. In this study, we demonstrate that low-dose exposure to polystyrene microplastics (PSMPs) leads to severely abnormal reproduction in females, manifested by oocyte meiotic maturation defect. Mechanistically, PSMPs exposure induce the overactivation of cell metabolism pathways, insufficient HDACs, and H4K16 hyperacetylation in oocytes both <i>in vivo</i> and <i>in vitro</i>. When an HDAC3 inhibitor is added, the oocyte maturation defect, overactivation of cell metabolism pathways, and H4K16 hyperacetylation are recapitulated. Conversely, the overexpression of HDAC3 can rescue the defects in meiotic maturation induced by PSMPs. Our observations suggest a direct link between the maturation defects caused by PSMPs and HDAC3 insufficiency. Thus, we propose potential treatments to address the meiotic maturation defect of oocytes in women highly exposed to MPs by activating or supplying HDAC3.</p>

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Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency

  • 期刊论文

  • 发表日期：

    2025年2月13日

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  • Qi Zhao,
  • Ming Zong,
  • Entong Song,
  • Hongye Linghu,
  • Xuanwen Li,
  • Baicui Wang,
  • Songling Xiao,
  • Wanchun Guan,
  • Jianzhong Su,
  • Jiaming Zhang,
  • Jingzhang Ji,
  • Qingran Kong

摘要

Microplastics (MPs) are considered one of the main causes of male and female infertility. However, the reproductive toxicity and its related mechanisms are currently understood primarily through animal models with acute exposure to MPs. In this study, we demonstrate that low-dose exposure to polystyrene microplastics (PSMPs) leads to severely abnormal reproduction in females, manifested by oocyte meiotic maturation defect. Mechanistically, PSMPs exposure induce the overactivation of cell metabolism pathways, insufficient HDACs, and H4K16 hyperacetylation in oocytes both in vivo and in vitro. When an HDAC3 inhibitor is added, the oocyte maturation defect, overactivation of cell metabolism pathways, and H4K16 hyperacetylation are recapitulated. Conversely, the overexpression of HDAC3 can rescue the defects in meiotic maturation induced by PSMPs. Our observations suggest a direct link between the maturation defects caused by PSMPs and HDAC3 insufficiency. Thus, we propose potential treatments to address the meiotic maturation defect of oocytes in women highly exposed to MPs by activating or supplying HDAC3.