<p>Organic luminescent materials with tunable luminescent properties have attracted considerable interest and demonstrated promising application potential. Molecular conformation is a crucial consideration in regulating luminescence, as it significantly impacts photophysical properties, including emission color, lifetime, and efficiency. Conformational changes are influenced by molecular intrinsic structures, demonstrating high designability. Moreover, the process of conformational changes is sensitive to external factors, which allows for the real-time regulation of luminescent properties via macroscopic methods. Therefore, molecules with tunable conformations are ideal candidates for constructing multifunctional luminescent materials and have witnessed remarkable progress over recent decades. In an attempt to highlight this type of molecule, this review focuses on the recent advances in conformation-tunable organic luminescent molecules, including their design, mechanism, properties, and applications. Representative molecules and structures are summarized and classified into two categories, including rotatable and bendable, according to the structural features of their conformational changes. Moreover, the challenges facing this field and future directions are also discussed.</p>