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<p>The cell membrane serves as a dynamic interface that mediates continuous communication between cells and their surroundings. Functionalizing the cell membrane with molecules or nanomaterials can modulate cellular behaviors and broaden cellular functionalities. In recent years, DNA materials have attracted growing attention as a versatile platform for surface engineering, owing to their molecular programmability, structural precision, and biocompatibility. This review provides an overview of the emerging strategies that employ DNA materials to remodel the cell membrane. It begins by summarizing the current technological strategies for modifying the cell membrane using DNA materials, encompassing both chemically mediated and biologically driven approaches. Subsequently, it points out the recent improvements in utilizing these technologies to understand cellular processes, govern cell behaviors and redefine cell functionalities. Finally, the challenges facing this emerging field are examined, followed by a discussion on future perspectives and potential directions for continued development.</p>

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DNA materials for cell-surface engineering: anchoring strategies, process monitoring, and functional reprogramming

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Wumeng Yin,
  • Xingyu Chen,
  • Yuhan Liu,
  • Ye Chen,
  • Yang Gao,
  • Taoran Tian,
  • Yunfeng Lin,
  • Xiaoxiao Cai

摘要

The cell membrane serves as a dynamic interface that mediates continuous communication between cells and their surroundings. Functionalizing the cell membrane with molecules or nanomaterials can modulate cellular behaviors and broaden cellular functionalities. In recent years, DNA materials have attracted growing attention as a versatile platform for surface engineering, owing to their molecular programmability, structural precision, and biocompatibility. This review provides an overview of the emerging strategies that employ DNA materials to remodel the cell membrane. It begins by summarizing the current technological strategies for modifying the cell membrane using DNA materials, encompassing both chemically mediated and biologically driven approaches. Subsequently, it points out the recent improvements in utilizing these technologies to understand cellular processes, govern cell behaviors and redefine cell functionalities. Finally, the challenges facing this emerging field are examined, followed by a discussion on future perspectives and potential directions for continued development.