<p>As organic fluorescent materials with single-mode stimulus-responsive anticounterfeiting and information encryption are easily cracked and counterfeited, the development of advanced and sophisticated dual-mode fluorescent materials is essential. Herein, we successfully fabricate a diverse stimuli-responsive salicylaldehyde Schiff base derivative (G), achieving controllable dual-mode changes in both fluorescence intensity and wavelength through the host-guest interaction and acid-base response. The significant enhancement in fluorescence intensity as well as the 10-fold increase in quantum yield are simultaneously achieved by the formation of host-guest inclusion between γ-cyclodextrin (γ-CD) and G, caused by the spatial confinement effect of γ-CD. Additionally, the fluorescence wavelength of G redshifts approximately 30 nm via the deprotonation by increasing pH value, leading to a remarkable change in fluorescence from green to yellow and a color change from clear and transparent to yellow. The process is also reversible by adding acid. The conformational and orbital distributions of G during the treatment of different stimuli are studied by theoretical calculations. According to its unique properties, the molecule is applied for anticounterfeiting and dynamic information encryption.</p>