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<p>An <i>N</i>-heterocyclic carbene (NHC)-catalyzed [3+3] cycloaddition reaction is developed for the enantio- and diastereoselective synthesis of tricyclic pyrimidine rings bearing contiguous C–N and C–C stereogenic axes. The chiral products were obtained in moderate yields and excellent enantio- and diastereoselectivities. Notably, these functionalized molecules exhibit significant potential applications in organic synthesis and bactericide development.</p>

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N-heterocyclic carbene-catalyzed enantio- and diastereoselective synthesis of tricyclic pyrimidine rings bearing contiguous C–N and C–C stereogenic axes

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Liya Cao,
  • Xiaolin Peng,
  • Zhichao Jin,
  • Tingting Li

摘要

An N-heterocyclic carbene (NHC)-catalyzed [3+3] cycloaddition reaction is developed for the enantio- and diastereoselective synthesis of tricyclic pyrimidine rings bearing contiguous C–N and C–C stereogenic axes. The chiral products were obtained in moderate yields and excellent enantio- and diastereoselectivities. Notably, these functionalized molecules exhibit significant potential applications in organic synthesis and bactericide development.