<p>Organoboron compounds are highly versatile building blocks in modern organic synthesis, pharmaceuticals, and materials science, offering unique reactivity and stability for the assembly of complex molecular structures. The hydroboration of allenes stands out as a straightforward method for the preparation of allyl and alkenyl boranes. Nonetheless, achieving precise control over regio- and stereoselectivity in these reactions presents significant challenges. In this review, we have systematically summarized the selective hydroboration of allenes catalyzed by a range of transition metals, including platinum, copper, palladium, cobalt, nickel, and ruthenium catalysts. The significant advancements, current limitations, and future perspective for the transition metal-catalyzed selective hydroboration are also highlighted. Moreover, we hope that this review will help understand more about the catalytic hydroboration of allenes and stimulate the further development of both allene and organoboron chemistry.</p>

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Transition metal-catalyzed selective hydroboration of allenes

  • Yun-Xuan Tan,
  • Li-Juan Song,
  • Xinhao Zhang,
  • Yun-Dong Wu,
  • Jianwei Sun

摘要

Organoboron compounds are highly versatile building blocks in modern organic synthesis, pharmaceuticals, and materials science, offering unique reactivity and stability for the assembly of complex molecular structures. The hydroboration of allenes stands out as a straightforward method for the preparation of allyl and alkenyl boranes. Nonetheless, achieving precise control over regio- and stereoselectivity in these reactions presents significant challenges. In this review, we have systematically summarized the selective hydroboration of allenes catalyzed by a range of transition metals, including platinum, copper, palladium, cobalt, nickel, and ruthenium catalysts. The significant advancements, current limitations, and future perspective for the transition metal-catalyzed selective hydroboration are also highlighted. Moreover, we hope that this review will help understand more about the catalytic hydroboration of allenes and stimulate the further development of both allene and organoboron chemistry.