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<p>Light-driven theranostics, so-called phototheranostics, represents one of the most momentous advances for cancer treatment, of particular interest is fluorescence imaging (FLI)-navigated photodynamic therapy (PDT). Development of prominent phototheranostic agent synchronously sharing high reactive oxygen species (ROS) production and conspicuous absorption/emission performance in terms of wavelength and intensity, still remains an appealing yet significantly challenging task. Herein, a molecular fluorination strategy was tactfully exploited to subtly regulate aggregation-induced emission (AIE)-featured photosensitizers, and the optimized agent FPIBT was obtained. The integration of beneficial fluorine results in extended emission wavelength tailing in the second near-infrared region and enhanced molar extinction coefficient, and promotes the intersystem crossing process by reducing energy gap between the S<sub>1</sub> and T<sub><i>n</i></sub> and increasing spin-orbit coupling constant, thus significantly improves ROS production capacity. By employing FPIBT nanoparticles, the unprecedented performance on NIR-II FLI-guided PDT towards nasopharyngeal carcinoma in mouse model is witnessed by the precise tumor diagnosis and efficient tumor elimination outcomes.</p>

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Molecular fluorination strategy for regulating NIR AIEgens to boost phototheranostics of nasopharyngeal carcinoma

  • 期刊论文

  • 发表日期：

    2025年1月20日

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  • Ping Zheng,
  • Yuxun Ding,
  • Alim Abdurahman,
  • Jun Zhu,
  • Leyuan Tian,
  • Yi Liu,
  • Qian Liu,
  • Lei Wang,
  • Dong Wang,
  • Ben Zhong Tang

摘要

Light-driven theranostics, so-called phototheranostics, represents one of the most momentous advances for cancer treatment, of particular interest is fluorescence imaging (FLI)-navigated photodynamic therapy (PDT). Development of prominent phototheranostic agent synchronously sharing high reactive oxygen species (ROS) production and conspicuous absorption/emission performance in terms of wavelength and intensity, still remains an appealing yet significantly challenging task. Herein, a molecular fluorination strategy was tactfully exploited to subtly regulate aggregation-induced emission (AIE)-featured photosensitizers, and the optimized agent FPIBT was obtained. The integration of beneficial fluorine results in extended emission wavelength tailing in the second near-infrared region and enhanced molar extinction coefficient, and promotes the intersystem crossing process by reducing energy gap between the S1 and Tn and increasing spin-orbit coupling constant, thus significantly improves ROS production capacity. By employing FPIBT nanoparticles, the unprecedented performance on NIR-II FLI-guided PDT towards nasopharyngeal carcinoma in mouse model is witnessed by the precise tumor diagnosis and efficient tumor elimination outcomes.